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© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Objectives: Diabetic peripheral neuropathy (DPN) is a chronic complication of diabetes mellitus (DM) with symptoms like intense pain and impaired quality of life. This condition has no treatment; instead, the pain is managed with various antidepressants, including duloxetine. The aim of this study is to analyze the evidence on the efficacy of duloxetine in the management of DPN. Methods: A systematic search in different databases was conducted using the keywords “diabetic neuropathy”, “duloxetine therapy”, “neuropathic pain”, and “Diabetes Mellitus”. Finally, eight studies were included in this meta-analysis. Results: All articles comparing duloxetine at different doses vs. a placebo reported significant differences in favor of duloxetine on pain scales like 24 h Average Pain Severity (standardized mean difference [SMD] = −1.06, confidence interval [CI] = −1.09 to −1.03, and p < 0.00001) and BPI Severity (SMD = −0.70, CI = −0.72 to −0.68, and p < 0.00001), among others. A total of 75% of the meta-analyses of studies comparing duloxetine at different doses showed a tendency in favor of the 120 mg/d dose. There were significant differences in favor of duloxetine when compared to routine care on the Euro Quality of Life (SMD = −0.04, CI = −0.04 to −0.03, and p < 0.00001) and SF-36 Survey (SMD = −5.86, CI = −6.28 to −5.44, and p < 0.00001) scales. There were no significant differences on the visual analog scale (VAS) when comparing duloxetine and gabapentin. Conclusions: Duloxetine appears to be effective in the management of DPN in different pain, symptom improvement, and quality of life scales.

Details

Title
Effectiveness of Duloxetine versus Other Therapeutic Modalities in Patients with Diabetic Neuropathic Pain: A Systematic Review and Meta-Analysis
Author
Valenzuela-Fuenzalida, Juan José 1 ; López-Chaparro, Michelle 2 ; Barahona-Vásquez, Marisol 2 ; Campos-Valdes, Javiera 2 ; Javiera Cordero Gonzalez 2 ; Nova-Baeza, Pablo 2   VIAFID ORCID Logo  ; Orellana-Donoso, Mathias 3 ; Suazo-Santibañez, Alejandra 4 ; Oyanedel-Amaro, Gustavo 5 ; Héctor Gutiérrez Espinoza 6   VIAFID ORCID Logo 

 Departamento de Morfología, Facultad de Medicina, Universidad Andrés Bello, Santiago 8370146, Chile; [email protected] (J.J.V.-F.); [email protected] (M.L.-C.); [email protected] (M.B.-V.); [email protected] (J.C.-V.); [email protected] (J.C.G.); [email protected] (P.N.-B.); [email protected] (M.O.-D.); Departamento de Ciencias Química y Biológicas, Facultad de Ciencias de la Salud, Universidad Bernardo O’Higgins, Santiago 8370993, Chile 
 Departamento de Morfología, Facultad de Medicina, Universidad Andrés Bello, Santiago 8370146, Chile; [email protected] (J.J.V.-F.); [email protected] (M.L.-C.); [email protected] (M.B.-V.); [email protected] (J.C.-V.); [email protected] (J.C.G.); [email protected] (P.N.-B.); [email protected] (M.O.-D.) 
 Departamento de Morfología, Facultad de Medicina, Universidad Andrés Bello, Santiago 8370146, Chile; [email protected] (J.J.V.-F.); [email protected] (M.L.-C.); [email protected] (M.B.-V.); [email protected] (J.C.-V.); [email protected] (J.C.G.); [email protected] (P.N.-B.); [email protected] (M.O.-D.); Escuela de Medicina, Universidad Finis Terrae, Santiago 7501015, Chile 
 Faculty of Health and Social Sciences, Universidad de Las Américas, Santiago 8370040, Chile; [email protected] 
 Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Santiago 7501019, Chile; [email protected] 
 One Health Research Group, Universidad de las Americas, Quito 170124, Ecuador 
First page
856
Publication year
2024
Publication date
2024
Publisher
MDPI AG
e-ISSN
14248247
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3084973638
Copyright
© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.