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© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

The chemical composition of extracts (CEs) and essential oils (EOs) from Tetradenia riparia leaves, flower buds, and stems was analyzed. Antiproliferative activity against tumor cell lines, NO production inhibition, and antioxidant and antiviral activities were assessed. The CEs contained flavonoids, phenolic acids, coumarins, and saturated fatty acids. The EOs included monoterpenes, oxygenated sesquiterpenes, and diterpenes. NO production inhibition ranged from 76 to 247 µg mL−1, and antiproliferative activity exhibited GI50 between 20 and >204 µg mL−1, with low cytotoxicity (SI: 1.08 to 4.75). Reactive oxygen species inhibition ranged from 45 to 82%. Antioxidant activity varied when determined by the 2,2-diphenyl-1-picrylhydrazyl radical scavenging assay (IC50: 0.51 to 8.47 mg mL−1) and ferric reducing antioxidant power (0.35 to 0.81 µM ferrous sulfate per mg). The reduction in β-carotene–linoleic acid co-oxidation varied between 76.13 and 102.25%. The total phenolic content of CEs and EOs was 10.70 to 111.68 µg gallic acid mg−1. Antiviral activity against herpes simplex virus type 1 (HSV-1) showed an EC50 between 9.64 and 24.55 µg mL−1 and an SI between 8.67 and 15.04. Leaf EOs exhibited an EC50 of 9.64 µg mL−1 and an SI of 15.04. Our study unveils the diverse chemical composition and multifaceted pharmacological properties of T. riparia, demonstrating its potential as a valuable source of bioactive compounds for therapeutic applications.

Details

Title
Antioxidant Activity, Antiproliferative Activity, Antiviral Activity, NO Production Inhibition, and Chemical Composition of Essential Oils and Crude Extracts of Leaves, Flower Buds, and Stems of Tetradenia riparia
Author
Jéssica da Silva Sena 1 ; Selma Alves Rodrigues 2 ; Sakumoto, Karina 3 ; Inumaro, Rodrigo Sadao 4 ; González-Maldonado, Pamela 5   VIAFID ORCID Logo  ; Mendez-Scolari, Emilio 5   VIAFID ORCID Logo  ; PiauJr, Ranulfo 2   VIAFID ORCID Logo  ; Daniela Dib Gonçalves 6   VIAFID ORCID Logo  ; Mandim, Filipa 7   VIAFID ORCID Logo  ; Vaz, Josiana 7   VIAFID ORCID Logo  ; Gonçalves, José Eduardo 8   VIAFID ORCID Logo  ; Sotelo, Pablo Hernan 5   VIAFID ORCID Logo  ; Juliana Silveira do Valle 9   VIAFID ORCID Logo  ; Zilda Cristiani Gazim 9 

 Graduate Program in Biotechnology Applied to Agriculture, Universidade Paranaense, Umuarama 87502-210, Brazil; [email protected] (J.d.S.S.); [email protected] (J.S.d.V.) 
 Graduate Program in Animal Science with Emphasis on Bioactive Products, Universidade Paranaense, Umuarama 87502-210, Brazil; [email protected] (S.A.R.); [email protected] (D.D.G.) 
 Graduate Program in Medicinal and Phytotherapeutic Plants in Primary Care, Universidade Paranaense, Umuarama 87502-210, Brazil; [email protected] 
 Graduate Program in Clean Technologies, UniCesumar, Maringá 87050-390, Brazil; [email protected] (R.S.I.); [email protected] (J.E.G.) 
 Biotechnology Department, Facultad de Ciencias Químicas, Universidad Nacional de Asunción, San Lorenzo 111421, Paraguay; [email protected] (P.G.-M.); [email protected] (E.M.-S.); [email protected] (P.H.S.) 
 Graduate Program in Animal Science with Emphasis on Bioactive Products, Universidade Paranaense, Umuarama 87502-210, Brazil; [email protected] (S.A.R.); [email protected] (D.D.G.); Graduate Program in Medicinal and Phytotherapeutic Plants in Primary Care, Universidade Paranaense, Umuarama 87502-210, Brazil; [email protected] 
 Centro de Investigação de Montanha (CIMO), Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, Portugal; [email protected] (F.M.); [email protected] (J.V.); Laboratório Associado para a Sustentabilidade e Tecnologia em Regiões de Montanha (SusTEC), Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, Portugal 
 Graduate Program in Clean Technologies, UniCesumar, Maringá 87050-390, Brazil; [email protected] (R.S.I.); [email protected] (J.E.G.); Cesumar Institute of Science, Technology and Innovation, UniCesumar, Maringá 87050-390, Brazil 
 Graduate Program in Biotechnology Applied to Agriculture, Universidade Paranaense, Umuarama 87502-210, Brazil; [email protected] (J.d.S.S.); [email protected] (J.S.d.V.); Graduate Program in Animal Science with Emphasis on Bioactive Products, Universidade Paranaense, Umuarama 87502-210, Brazil; [email protected] (S.A.R.); [email protected] (D.D.G.) 
First page
888
Publication year
2024
Publication date
2024
Publisher
MDPI AG
e-ISSN
14248247
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3084975084
Copyright
© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.