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© 2023. This work is published under http://creativecommons.org/licenses/by-nc/3.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Background

Seborrheic keratoses (SK) are the most common acquired benign tumor that affects middle‐aged or older adults with great cosmetic concern. Clinical and histopathological similarities of SK and common warts have been addressed by investigating the possible presence of human papillomavirus (HPV) DNA in SK. Previous studies suggested the association between α‐genus HPV and SK located on genital skin, whereas the causal relationship between α‐HPV and non‐genital SK remains controversial.

Aim

This study aimed to clarify the pathogenic involvement of α‐HPV in the development of non‐genital SK.

Methods

We analyzed α‐HPV DNA prevalence and HPV genotypes using a PCR‐based microarray on 51 skin samples presenting with histologically confirmed SK without any malignant changes. Correlation between the histological subtype of SK and their HPV DNA‐positive reactivity was also evaluated.

Results

Of 51 non‐genital SK, two (3.9%) skin samples were positive for α‐HPV DNA; high‐risk HPV 31 and low‐risk HPV 42 were found. Evaluation of HPV prevalence in different histological types of SK showed that both HPV‐positive cases were acanthotic type; 14.3% of acanthotic SK lesions were positive, while all of the other types were negative for α‐HPV.

Conclusions

This study demonstrates that α‐HPV positivity is very rare in common non‐genital SK. The rare α‐HPV‐positive SK lesions histologically belonged to the acanthotic type, implying a potential impact of HPV infection on epidermal hyperproliferation. Although a possible association cannot be excluded, our findings suggest that α‐HPV is not a major causative factor for non‐genital SK.

Details

Title
Relationship between α‐genus human papillomavirus and non‐genital seborrheic keratosis: Report of new cases and updated review
Author
Nellessen, Tobias 1 ; Aoki, Rui 1 ; Kammerbauer, Claudia 1 ; Clanner‐Engelshofen, Benjamin M. 1 ; French, Lars E. 1 ; Reinholz, Markus 1   VIAFID ORCID Logo 

 The Department of Dermatology and Allergology, University Hospital of Munich LMU, Munich, Germany 
Pages
306-310
Section
DERMATOLOGIC SURGERY ARTICLES
Publication year
2023
Publication date
Jan 1, 2023
Publisher
John Wiley & Sons, Inc.
ISSN
14732130
e-ISSN
14732165
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3090613456
Copyright
© 2023. This work is published under http://creativecommons.org/licenses/by-nc/3.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.