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© 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Messenger RNA (mRNA) and ribosomal RNA are involved in gene expression and protein synthesis. [...]the RNA-binding small molecules would be unlikely to modulate the cellular levels or the activities of the RNA molecules. [...]the activity of RNA degraders is influenced by the endogenous expression level of RNase L, which varies among different cell lines.

Details

Title
Small‐molecule drugs as RNA‐targeted degraders
Author
Huang, Luyi 1 ; Zou, Jun 2   VIAFID ORCID Logo 

 Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Department of Infectious Diseases, Institute for Viral Hepatitis, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China 
 Center for Clinical Translational Innovations, State Key Laboratory of Biotherapy, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, China 
Section
HIGHLIGHT
Publication year
2023
Publication date
Jun 1, 2023
Publisher
John Wiley & Sons, Inc.
e-ISSN
27696456
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3090875261
Copyright
© 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.