Full text

Turn on search term navigation

© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Arrhythmogenic cardiomyopathy (AC) is a hereditary cardiac disorder characterized by the gradual replacement of cardiomyocytes with fibrous and adipose tissue, leading to ventricular wall thinning, chamber dilation, arrhythmias, and sudden cardiac death. Despite advances in treatment, disease management remains challenging. Animal models, particularly mice and zebrafish, have become invaluable tools for understanding AC’s pathophysiology and testing potential therapies. Mice models, although useful for scientific research, cannot fully replicate the complexity of the human AC. However, they have provided valuable insights into gene involvement, signalling pathways, and disease progression. Zebrafish offer a promising alternative to mammalian models, despite the phylogenetic distance, due to their economic and genetic advantages. By combining animal models with in vitro studies, researchers can comprehensively understand AC, paving the way for more effective treatments and interventions for patients and improving their quality of life and prognosis.

Details

Title
In Vivo Approaches to Understand Arrhythmogenic Cardiomyopathy: Perspectives on Animal Models
Author
Risato, Giovanni 1   VIAFID ORCID Logo  ; Raquel Brañas Casas 2   VIAFID ORCID Logo  ; Cason, Marco 3   VIAFID ORCID Logo  ; Maria Bueno Marinas 3   VIAFID ORCID Logo  ; Pinci, Serena 3 ; De Gaspari, Monica 3 ; Visentin, Silvia 4 ; Rizzo, Stefania 3   VIAFID ORCID Logo  ; Thiene, Gaetano 3   VIAFID ORCID Logo  ; Basso, Cristina 3   VIAFID ORCID Logo  ; Pilichou, Kalliopi 3   VIAFID ORCID Logo  ; Tiso, Natascia 2   VIAFID ORCID Logo  ; Celeghin, Rudy 3   VIAFID ORCID Logo 

 Department of Cardio-Thoraco-Vascular Sciences and Public Health, University of Padua, I-35128 Padua, Italy; [email protected] (G.R.); [email protected] (M.C.); [email protected] (M.B.M.); [email protected] (S.P.); [email protected] (M.D.G.); [email protected] (S.R.); [email protected] (G.T.); [email protected] (C.B.); [email protected] (K.P.); [email protected] (R.C.); Department of Biology, University of Padua, I-35131 Padua, Italy; [email protected]; Department of Women’s and Children’s Health, University of Padua, I-35128 Padua, Italy; [email protected] 
 Department of Biology, University of Padua, I-35131 Padua, Italy; [email protected] 
 Department of Cardio-Thoraco-Vascular Sciences and Public Health, University of Padua, I-35128 Padua, Italy; [email protected] (G.R.); [email protected] (M.C.); [email protected] (M.B.M.); [email protected] (S.P.); [email protected] (M.D.G.); [email protected] (S.R.); [email protected] (G.T.); [email protected] (C.B.); [email protected] (K.P.); [email protected] (R.C.) 
 Department of Women’s and Children’s Health, University of Padua, I-35128 Padua, Italy; [email protected] 
First page
1264
Publication year
2024
Publication date
2024
Publisher
MDPI AG
e-ISSN
20734409
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3090881276
Copyright
© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.