Full text

Turn on search term navigation

© The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Lymphocytes are important for protective immunity against infections and cancers, and dysregulation of the immune system may lead to systemic lupus erythematosus (SLE). Metabolic adaptation regulates the fate of lymphocytes. The immune microenvironment is vital role in both SLE and gynecological malignancies. The disruption of the immune microenvironment in SLE is one of the key factors leading to disease occurrence. Overactive autoimmunity indices the body to attack its own tissues, leading to the formation of immune complexes that further trigger tissue damage and inflammation. This imbalance in the immune microenvironment affects the progression of SLE and may also indirectly affect the occurrence of gynecological cancers. For gynecological cancers, immune cells, cytokines, and chemokines in the tumor microenvironment jointly comprise a complex network, and their interactions determine cancer growth, invasion, and metastasis. Mendelian randomization analysis revealed that SLE does not have a statistically significant causal effect on the risk of common cancers of the female reproductive system such as cervical, endometrial, and ovarian cancers in the European population. However, the odds ratio < 1 in the inverse variance weighted results suggest the potential of SLE as a protective factor for endometrial cancer.

Details

Title
Association between systemic lupus erythematosus and common female reproductive system malignancies
Author
Sirong, Cheng 1 ; Zhang, Kun 2 ; Yang, Yinxia 1 ; Zhong, Yuxuan 1 ; Sun, Pengyu 1 ; Zanhong, Wang 1 

 Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Department of Obstetrics and Gynecology, Shanxi Bethune Hospital, Taiyuan, China (GRID:grid.470966.a) 
 Shanxi Provincial People’s Hospital, Department of Surgical Oncology of Gastrointestinal Pancreatic Tumors, Taiyuan, China (GRID:grid.440288.2) (ISNI:0000 0004 1758 0451) 
Pages
341
Publication year
2024
Publication date
Dec 2024
Publisher
Springer Nature B.V.
e-ISSN
27306011
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3091016299
Copyright
© The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.