Histopathological Effects of Boric Acid Solution on Middle Ear Mucosa in Guinea Pigs

Abstract

[LANGUAGE= "English"] Objectives: In this study, we aimed to histopathologically reveal the effects of 4% boric acid solution used in diseases such as external otitis and otomycosis, in which the tympanum and tympanic membrane do not participate in the infection process, on the healthy tympanic mucosa. Methods: A, B, C, D group guinea pigs were administered 4% boric acid solution for 7, 14, 21, 28 days respectively. The tympanic bullae of group A, B, C, D guinea pigs were excised on the 8,15, 22,29 days respectively. Results: While 5 of the samples taken from the right tympanic bullae of group A were grade 2 and 1 was grade 3, all of the samples taken from the right tympanic bulla of the subjects in group B were grade 3, all samples taken from the right tympanic bullae of the subjects in group C were grade 4, and all of the right tympanic bullae of the subjects in group D were grade 4 regarding the histopathological changes. Conclusion: We determined that the use of 4% boric acid solution for more than 1 week in cases accompanied by tympanic membrane perforation such as chronic otitis media led to an increase in the inflammation score and histo?pathological changes in the tympanic mucosa.

Alternate abstract:

Objectives: In this study, we aimed to histopathologically reveal the effects of 4% boric acid solution used in diseases such as external otitis and otomycosis, in which the tympanum and tympanic membrane do not participate in the infection process, on the healthy tympanic mucosa. Methods: A, B, C, D group guinea pigs were administered 4% boric acid solution for 7, 14, 21, 28 days respectively. The tympanic bullae of group A, B, C, D guinea pigs were excised on the 8,15, 22,29 days respectively. Results: While 5 of the samples taken from the right tympanic bullae of group A were grade 2 and 1 was grade 3, all of the samples taken from the right tympanic bulla of the subjects in group B were grade 3, all samples taken from the right tympanic bullae of the subjects in group C were grade 4, and all of the right tympanic bullae of the subjects in group D were grade 4 regarding the histopathological changes. Conclusion: We determined that the use of 4% boric acid solution for more than 1 week in cases accompanied by tympanic membrane perforation such as chronic otitis media led to an increase in the inflammation score and histo?pathological changes in the tympanic mucosa.