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Abstract
Mitochondrial dysregulation plays a significant role in the carcinogenesis. On the other hand, its destabilization strongly represses the viability and metastatic potential of cancer cells. Photodynamic and photothermal therapies (PDT and PTT) target mitochondria effectively, providing innovative and non-invasive anticancer therapeutic modalities. Cyanine dyes, with strong mitochondrial selectivity, show significant potential in enhancing PDT and PTT. The potential and limitations of cyanine dyes for mitochondrial PDT and PTT are discussed, along with their applications in combination therapies, theranostic techniques, and optimal delivery systems. Additionally, novel approaches for sonodynamic therapy using photoactive cyanine dyes are presented, highlighting advances in cancer treatment.
Photodynamic and photothermal therapies (PDT and PTT) target mitochondria effectively, providing innovative and non-invasive anticancer therapeutic modalities. Here, the authors summarize the promise and limitations of cyanine dyes in enhancing mitochondrial PDT and PTT in cancer treatment.
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1 Charles University, BIOCEV, First Faculty of Medicine, Prague, Czech Republic (GRID:grid.4491.8) (ISNI:0000 0004 1937 116X); Charles University and General University Hospital in Prague, Department of Paediatrics and Inherited Metabolic Disorders, First Faculty of Medicine, Prague, Czech Republic (GRID:grid.411798.2) (ISNI:0000 0000 9100 9940)
2 Charles University, BIOCEV, First Faculty of Medicine, Prague, Czech Republic (GRID:grid.4491.8) (ISNI:0000 0004 1937 116X)
3 Masaryk University, Department of Pathological Physiology, Faculty of Medicine, Brno, Czech Republic (GRID:grid.10267.32) (ISNI:0000 0001 2194 0956)
4 Charles University, BIOCEV, First Faculty of Medicine, Prague, Czech Republic (GRID:grid.4491.8) (ISNI:0000 0004 1937 116X); Charles University and General University Hospital in Prague, Department of Paediatrics and Inherited Metabolic Disorders, First Faculty of Medicine, Prague, Czech Republic (GRID:grid.411798.2) (ISNI:0000 0000 9100 9940); Masaryk University, Department of Pathological Physiology, Faculty of Medicine, Brno, Czech Republic (GRID:grid.10267.32) (ISNI:0000 0001 2194 0956); Masaryk University, Department of Physiology, Faculty of Medicine, Brno, Czech Republic (GRID:grid.10267.32) (ISNI:0000 0001 2194 0956)
5 Masaryk University, Department of Physiology, Faculty of Medicine, Brno, Czech Republic (GRID:grid.10267.32) (ISNI:0000 0001 2194 0956)
6 Charles University and General University Hospital in Prague, 1st Department of Surgery-Department of Abdominal, Thoracic Surgery and Traumatology, First Faculty of Medicine, Prague, Czech Republic (GRID:grid.411798.2) (ISNI:0000 0000 9100 9940)
7 Charles University and General University Hospital in Prague, Department of Paediatrics and Inherited Metabolic Disorders, First Faculty of Medicine, Prague, Czech Republic (GRID:grid.411798.2) (ISNI:0000 0000 9100 9940)