Olfactory bulb astrocytes link social transmission of stress to cognitive adaptation in male mice

Abstract

Emotions and behavior can be affected by social chemosignals from conspecifics. For instance, olfactory signals from stressed individuals induce stress-like physiological and synaptic changes in naïve partners. Direct stress also alters cognition, but the impact of socially transmitted stress on memory processes is currently unknown. Here we show that exposure to chemosignals produced by stressed individuals is sufficient to impair memory retrieval in unstressed male mice. This requires astrocyte control of information in the olfactory bulb mediated by mitochondria-associated CB1 receptors (mtCB1). Targeted genetic manipulations, in vivo Ca²⁺ imaging and behavioral analyses reveal that mtCB1-dependent control of mitochondrial Ca²⁺ dynamics is necessary to process olfactory information from stressed partners and to define their cognitive consequences. Thus, olfactory bulb astrocytes provide a link between social odors and their behavioral meaning.

By focusing attention to potential dangers, social transmission of stress is key for animal survival. Here the authors show that CB1-dependent control of astrocyte mitochondria is necessary to assign cognitive value to odorants from stressed conspecifics.