Abstract

The One Health approach, recognizing the interconnectedness of human, animal, and environmental health, has gained significance amid emerging zoonotic diseases and antibiotic resistance concerns. This paper aims to demonstrate the utility of a collaborative tool, the SIEGA, for monitoring infectious diseases across domains, fostering a comprehensive understanding of disease dynamics and risk factors, highlighting the pivotal role of One Health surveillance systems. Raw whole-genome sequencing is processed through different species-specific open software that additionally reports the presence of genes associated to anti-microbial resistances and virulence. The SIEGA application is a Laboratory Information Management System, that allows customizing reports, detect transmission chains, and promptly alert on alarming genetic similarities. The SIEGA initiative has successfully accumulated a comprehensive collection of more than 1900 bacterial genomes, including Salmonella enterica, Listeria monocytogenes, Campylobacter jejuni, Escherichia coli, Yersinia enterocolitica and Legionella pneumophila, showcasing its potential in monitoring pathogen transmission, resistance patterns, and virulence factors. SIEGA enables customizable reports and prompt detection of transmission chains, highlighting its contribution to enhancing vigilance and response capabilities. Here we show the potential of genomics in One Health surveillance when supported by an appropriate bioinformatic tool. By facilitating precise disease control strategies and antimicrobial resistance management, SIEGA enhances global health security and reduces the burden of infectious diseases. The integration of health data from humans, animals, and the environment, coupled with advanced genomics, underscores the importance of a holistic One Health approach in mitigating health threats.

Details

Title
The integrated genomic surveillance system of Andalusia (SIEGA) provides a One Health regional resource connected with the clinic
Author
Casimiro-Soriguer, Carlos S. 1 ; Pérez-Florido, Javier 2 ; Robles, Enrique A. 3 ; Lara, María 3 ; Aguado, Andrea 3 ; Rodríguez Iglesias, Manuel A. 4 ; Lepe, José A. 5 ; García, Federico 6 ; Pérez-Alegre, Mónica 7 ; Andújar, Eloísa 7 ; Jiménez, Victoria E. 7 ; Camino, Lola P. 7 ; Loruso, Nicola 8 ; Ameyugo, Ulises 8 ; Vazquez, Isabel María 8 ; Lozano, Carlota M. 8 ; Chaves, J. Alberto 8 ; Dopazo, Joaquin 9 

 Andalusian Public Foundation Progress and Health-FPS, Andalusian Platform for Computational Medicine, Seville, Spain; IBiS, University Hospital Virgen del Rocío/CSIC/University of Seville, Institute of Biomedicine of Seville, Seville, Spain (GRID:grid.414816.e) (ISNI:0000 0004 1773 7922) 
 Andalusian Public Foundation Progress and Health-FPS, Andalusian Platform for Computational Medicine, Seville, Spain (GRID:grid.414816.e); IBiS, University Hospital Virgen del Rocío/CSIC/University of Seville, Institute of Biomedicine of Seville, Seville, Spain (GRID:grid.414816.e) (ISNI:0000 0004 1773 7922) 
 Andalusian Public Foundation Progress and Health-FPS, Andalusian Platform for Computational Medicine, Seville, Spain (GRID:grid.414816.e) 
 Servicio de Microbiología. Hospital Universitario Puerta del Mar, Cádiz, Spain (GRID:grid.411342.1) (ISNI:0000 0004 1771 1175) 
 IBiS, University Hospital Virgen del Rocío/CSIC/University of Seville, Institute of Biomedicine of Seville, Seville, Spain (GRID:grid.414816.e) (ISNI:0000 0004 1773 7922); Unidad Clínica Enfermedades Infecciosas, Microbiología y Medicina Preventiva, Hospital Universitario Virgen del Rocío, Servicio de Microbiología, Sevilla, Spain (GRID:grid.411109.c) (ISNI:0000 0000 9542 1158); Centro de Investigación Biomédica en Red en Enfermedades Infecciosas (CIBERINFEC), ISCIII, Madrid, Spain (GRID:grid.413448.e) (ISNI:0000 0000 9314 1427) 
 Centro de Investigación Biomédica en Red en Enfermedades Infecciosas (CIBERINFEC), ISCIII, Madrid, Spain (GRID:grid.413448.e) (ISNI:0000 0000 9314 1427); Servicio de Microbiología. Hospital Universitario San Cecilio, Granada, Spain (GRID:grid.459499.c); Instituto de Investigación Biosanitaria, Ibs.GRANADA, Granada, Spain (GRID:grid.507088.2) 
 CSIC University of Seville University Pablo de Olavide, Genomic Unit, Andalusian Molecular Biology and Regenerative Medicine Center (CABIMER), Seville, Spain (GRID:grid.15449.3d) (ISNI:0000 0001 2200 2355) 
 Consejería de Salud y Consumo- Junta de Andalucía, Dirección General de Salud Pública y Ordenación Farmacéutica, Seville, Spain (GRID:grid.484065.b) 
 Andalusian Public Foundation Progress and Health-FPS, Andalusian Platform for Computational Medicine, Seville, Spain (GRID:grid.484065.b); IBiS, University Hospital Virgen del Rocío/CSIC/University of Seville, Institute of Biomedicine of Seville, Seville, Spain (GRID:grid.414816.e) (ISNI:0000 0004 1773 7922) 
Pages
19200
Publication year
2024
Publication date
2024
Publisher
Nature Publishing Group
e-ISSN
20452322
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3094595624
Copyright
© The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.