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Abstract
The development of self-preserving personal care cosmetics represents a significant advancement in the cosmetics industry, offering safer and more natural alternatives to consumers. This study focused on the preparation of such formulations using multifunctional ingredients along with other cosmetic components. Five unique multifunctional ingredients (MFIs) were identified based on their antimicrobial properties: sodium coco PG-dimonium chloride phosphate, ricinoleic acid, palmitoleic acid, raspberry ketone, and sorbitan caprylate. Through meticulous experimentation, 150 combinations of MFIs were prepared and tested to understand their synergistic actions. From these trials, three synergistic antimicrobial compositions were determined: sodium coco PG-dimonium chloride phosphate: ricinoleic acid: raspberry ketone in the ratios 1:6.3:6.3 and 1:6.3:15.7. Sodium coco PG-dimonium chloride phosphate: palmitoleic acid: sorbitan caprylate at a ratio of 1:12.5:37.5. These synergistic compositions exhibited enhanced antimicrobial efficacy compared with their individual components, as evidenced by their lower Minimum Inhibitory Concentration values. Incorporating these formulations into three distinct personal care cosmetic products, including a color protection shampoo, body wash shower gel, and skin-lightening cream, the study further validated their effectiveness. A Preservation Challenge Test study revealed that all three antimicrobial compositions successfully preserved the cosmetic formulations for up to 28 days. This method of product preservation not only ensures consumer safety and stability but also reduces the need for potentially conventional preservatives. In conclusion, the appropriate use of multifunctional ingredients in combination with meticulous formulation techniques has led to the successful development of self-preserving personal care cosmetics. These formulations offer a promising avenue for the cosmetic industry, catering to the rising demand for natural, effective, and consumer-friendly cosmetic products.
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1 Vels Institute of Science Technology and Advanced Studies (VISTAS), Department of Pharmacognosy, School of Pharmaceutical Sciences, Pallavaram, Chennai, India (GRID:grid.412815.b) (ISNI:0000 0004 1760 6324)
2 Vels Institute of Science Technology and Advanced Studies (VISTAS), Department of Biotechnology, School of Life Sciences, Pallavaram, Chennai, India (GRID:grid.412815.b) (ISNI:0000 0004 1760 6324)
3 Ponnaiyah Ramajayam Institute of Science and Technology (PRIST), Department of Biochemistry, School of Arts and Science, Thanjavur, India (GRID:grid.412548.e) (ISNI:0000 0004 1761 0374)
4 Saveetha University, Department of Prosthodontics and Implantology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, India (GRID:grid.412431.1) (ISNI:0000 0004 0444 045X); Saveetha University, Centre for Marine Research and Conservation, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, India (GRID:grid.412431.1) (ISNI:0000 0004 0444 045X)
5 Pachaiyappas College, Department of Botany, Chennai, India (GRID:grid.413015.2) (ISNI:0000 0004 0505 215X)
6 King Saud University, Department of Botany and Microbiology, College of Science, Riyadh, Saudi Arabia (GRID:grid.56302.32) (ISNI:0000 0004 1773 5396)
7 Hindu College Moradabad (Mahatma Jyotiba Phule Rohilkhand University Bareilly), Department of Botany, Bareilly, India (GRID:grid.411529.a) (ISNI:0000 0001 0374 9998)
8 Saveetha University, Department of Prosthodontics and Implantology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, India (GRID:grid.412431.1) (ISNI:0000 0004 0444 045X); Saveetha University, Centre for Marine and Aquatic Research (CMAR), Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, India (GRID:grid.412431.1) (ISNI:0000 0004 0444 045X)