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Abstract
Premixed insulins are an important tool for glycemic control in persons with diabetes. Equally important in diabetes care is the selection of the most appropriate insulin regimen for a particular individual at a specific time. Currently, the choice of insulin regimens for initiation or intensification of therapy is a subjective decision. In this article, we share insights, which will help in rational and objective selection of premixed formulations for initiation and intensification of insulin therapy. The glycemic status and its variations in a person help to identify the most appropriate insulin regimen and formulation for him or her. The evolution of objective glucometric indices has enabled better glycemic monitoring of individuals with diabetes. Management of diabetes has evolved from a ‘glucocentric’ approach to a ‘patient-centered’ approach; patient characteristics, needs, and preferences should be evaluated when considering premixed insulin for treatment of diabetes.
Funding: Novo Nordisk, India.
Details
1 Bharti Hospital Karnal, Department of Endocrinology, Karnal, India (GRID:grid.470178.d) (ISNI:0000 0004 1803 0590)
2 Medical University of Warsaw, Department of Diabetology and Internal Medicine, Warsaw, Poland (GRID:grid.13339.3b) (ISNI:0000000113287408)
3 University of Melbourne, Department of General Practice, Melbourne, Australia (GRID:grid.1008.9) (ISNI:0000 0001 2179 088X)
4 Department of Family Medicine, Korle Bu Teaching Hospital, University of Ghana, School of Public Health Ghana, Accra, Ghana (GRID:grid.1008.9)
5 Diabetes Care and Research Centre, Department of Diabetology, Patna, India (GRID:grid.477262.2)
6 Chellaram Diabetes Institute, Department of Endocrinology, Pune, India (GRID:grid.477262.2)
7 University Hospital Center Mustapha, Department of Endocrinology and Diabetology, Algiers, Algeria (GRID:grid.477262.2)
8 Hedi Chaker University Hospital, Department of Endocrinology and Diabetology, Sfax, Tunisia (GRID:grid.413980.7)
9 Asfendyarov Kazakh National Medical University, Center of Diabetes, Clinic of Internal Diseases, Almaty, Republic of Kazakhstan (GRID:grid.443453.1) (ISNI:0000 0004 0387 8740)
10 Indra Gandhi Hospital, Department of Medicine, Male, Maldives (GRID:grid.443453.1)
11 Gaziantep University Hospital, Department of Endocrinology and Metabolism, Gaziantep, Turkey (GRID:grid.411549.c) (ISNI:0000000107049315)
12 St. Francis Hospital, Department of Diabetology, Nsambya, Uganda (GRID:grid.461238.a) (ISNI:0000 0004 0513 0541)
13 Donka Conakry University Hospital, Department of Endocrinology, Conakry, Guinea (GRID:grid.461238.a)
14 NMC Speciality Hospital, Department of Endocrinology, Dubai, United Arab Emirates (GRID:grid.461238.a)
15 Rangsit University, Rajavithi Hospital, Diabetes and Endocrinology Unit, College of Medicine, Bangkok, Thailand (GRID:grid.415633.6) (ISNI:0000 0004 0637 1304)
16 Lagos University Teaching Hospital, Department of Endocrinology, Lagos, Nigeria (GRID:grid.411283.d) (ISNI:0000 0000 8668 7085)
17 Mohammed V University, Department of Endocrinology and Diabetology, Faculty of Medicine and Pharmacie, Rabat, Morocco (GRID:grid.31143.34) (ISNI:0000 0001 2168 4024)
18 Myanmar Diabetes Association, Yangon, Myanmar (GRID:grid.31143.34)
19 Central Hospital, Department of Internal Medicine, Yaoundé, Cameroon (GRID:grid.460723.4) (ISNI:0000 0004 0647 4688)
20 Multidisciplinario de Diabetes Centre, Mexico City, Mexico (GRID:grid.460723.4)
21 St Vincent’s Hospital, Catholic University, Department of Endocrinology, Suwon, South Korea (GRID:grid.416965.9) (ISNI:0000 0004 0647 774X)
22 BIRDEM, Dhaka, Bangladesh (GRID:grid.420060.0) (ISNI:0000 0004 0371 3380)
23 Belarusian Medical Academy of Postgraduate Education, Department of Endocrinology, Minsk, Belarus (GRID:grid.466551.5)
24 Alexandria University, Department of Diabetes and Metabolism, Alexandria, Egypt (GRID:grid.7155.6) (ISNI:0000 0001 2260 6941)
25 Kabul University of Medical Sciences, Department of Internal Medicine, Division of Endocrinology, Metabolism and Diabetes, Kabul, Afghanistan (GRID:grid.442859.6) (ISNI:0000 0004 0410 1351)
26 Bach Mai Hospital, Department of Endocrinology, Hanoi, Vietnam (GRID:grid.414163.5) (ISNI:0000 0004 4691 4377)
27 Shree Hindu Mandal Hospital, Department of Diabetology, Dar es Salaam, Tanzania (GRID:grid.414163.5)
28 Parklands Medical Centre, Department of Endocrinology, Durban, South Africa (GRID:grid.414163.5)
29 Shaukat Khanum Memorial Cancer Hospital and Research Centre, Department of Endocrinology, Lahore, Pakistan (GRID:grid.415662.2) (ISNI:0000 0004 0607 9952)
30 Royal Oman Police Hospital, Department of Endocrinology, Muscat, Oman (GRID:grid.415662.2)
31 Norvic International Hospital, Department of Endocrinology, Kathmandu, Nepal (GRID:grid.415662.2)
32 National Hospital of Sri Lanka, Department of Diabetes and Endocrinology, Colombo, Sri Lanka (GRID:grid.415398.2) (ISNI:0000 0004 0556 2133)
33 National University of Malaysia Medical Center, Endocrine Unit, Department of Medicine, Kuala Lumpur, Malaysia (GRID:grid.412113.4) (ISNI:0000 0004 1937 1557)
34 Institute for Studies on Diabetes Foundation Inc, Marikina City, Philippines (GRID:grid.412113.4)





