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© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

The COVID-19 pandemic has posed significant risks to pregnant women and those recently pregnant, leading to heightened mortality and morbidity rates. Vaccination has emerged as a pivotal strategy in reducing COVID-19-related deaths and illnesses worldwide. However, the initial exclusion of pregnant individuals from most clinical trials raised concerns about vaccine safety in this population, contributing to vaccine hesitancy. This review aims to consolidate the existing literature to assess the safety and efficacy of COVID-19 vaccination in pregnant populations and neonatal outcomes. Diverse studies were included evaluating various aspects of safety for women and their newborns, encompassing mild to severe symptoms across different vaccines. The findings indicate the overall safety and efficacy of COVID-19 vaccination, with minimal adverse outcomes observed, including mild side effects like pain and fever. Although most studies reported the absence of severe adverse outcomes, isolated case reports have raised concerns about potential associations between maternal COVID-19 vaccination and conditions such as fetal supraventricular tachycardia and immune-mediated diseases. Our review underscores the importance of ongoing surveillance and monitoring to ensure vaccine safety in pregnant women. Overall, COVID-19 vaccination during pregnancy remains a safe and effective strategy, emphasizing the need for continued research and vigilance to safeguard maternal and fetal health.

Details

Title
Safety of COVID-19 Vaccination in Pregnancy: A Systematic Review
Author
Gerede, Angeliki 1 ; Daskalakis, Georgios 2   VIAFID ORCID Logo  ; Mikos, Themistoklis 3 ; Chatzakis, Christos 4   VIAFID ORCID Logo  ; Vavoulidis, Eleftherios 4   VIAFID ORCID Logo  ; Eleftheriades, Makarios 5   VIAFID ORCID Logo  ; Domali, Ekaterini 2   VIAFID ORCID Logo  ; Nikolettos, Konstantinos 1   VIAFID ORCID Logo  ; Oikonomou, Efthymios 1   VIAFID ORCID Logo  ; Antsaklis, Panagiotis 2   VIAFID ORCID Logo  ; Theodora, Marianna 2   VIAFID ORCID Logo  ; Psarris, Alexandros 2 ; Margioula-Siarkou, Chrysoula 4 ; Petousis, Stamatios 4   VIAFID ORCID Logo  ; Sofoklis Stavros 2 ; Potiris, Anastasios 2   VIAFID ORCID Logo  ; Athanasiadis, Apostolos 6 ; Dinas, Konstantinos 4   VIAFID ORCID Logo  ; Tsikouras, Panagiotis 1 ; Nikolettos, Nikolaos 1 ; Sotiriadis, Alexandros 4   VIAFID ORCID Logo 

 Unit of Maternal-Fetal-Medicine, Department of Obstetrics and Gynecology, Medical School, Democritus University of Thrake, GR-68100 Alexandroupolis, Greece; [email protected] (K.N.); [email protected] (E.O.); [email protected] (P.T.); [email protected] (N.N.) 
 First Department of Obstetrics and Gynecology, Medical School, National and Kapodistrian University of Athens, GR-11528 Athens, Greece; [email protected] (G.D.); [email protected] (E.D.); [email protected] (P.A.); [email protected] (M.T.); [email protected] (S.S.); [email protected] (A.P.) 
 First Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece; [email protected] 
 Second Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, GR-54640 Thessaloniki, Greece; [email protected] (C.C.); [email protected] (E.V.); [email protected] (C.M.-S.); [email protected] (S.P.); [email protected] (K.D.); [email protected] (A.S.) 
 Second Department of Obstetrics and Gynecology, Medical School, National and Kapodistrian University of Athens, GR-11528 Athens, Greece; [email protected] 
 Third Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, GR-54640 Thessaloniki, Greece; [email protected] 
First page
1775
Publication year
2024
Publication date
2024
Publisher
MDPI AG
e-ISSN
20754418
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3097910698
Copyright
© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.