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© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Background and Objectives: Genomic studies have identified several SNP loci associated with schizophrenia in East Asian populations. Environmental factors, particularly urbanization, play a significant role in schizophrenia development. This study aimed to identify schizophrenia susceptibility loci and characterize their biological functions and molecular pathways in Taiwanese urban Han individuals. Materials and Methods: Participants with schizophrenia were recruited from the Taiwan Precision Medicine Initiative at Tri-Service General Hospital. Genotype–phenotype association analysis was performed, with significant variants annotated and analyzed for functional relevance. Results: A total of 137 schizophrenia patients and 26,129 controls were enrolled. Ten significant variants (p < 1 × 10−5) and 15 expressed genes were identified, including rs1010840 (SOWAHC and RGPD6), rs11083963 (TRPM4), rs11619878 (LINC00355 and LINC01052), rs117010638 (AGBL1 and MIR548AP), rs1170702 (LINC01680 and LINC01720), rs12028521 (KAZN and PRDM2), rs12859097 (DMD), rs1556812 (ATP11A), rs78144262 (LINC00977), and rs9997349 (ENPEP). These variants and associated genes are involved in immune response, blood pressure regulation, muscle function, and the cytoskeleton. Conclusions: Identified variants and associated genes suggest a potential genetic predisposition to schizophrenia in the Taiwanese urban Han population, highlighting the importance of potential comorbidities, considering population-specific genetic and environmental interactions.

Details

Title
Identification of Schizophrenia Susceptibility Loci in the Urban Taiwanese Population
Author
Chih-Chung, Huang 1   VIAFID ORCID Logo  ; Wang, Yi-Guang 1   VIAFID ORCID Logo  ; Chun-Lun Hsu 2   VIAFID ORCID Logo  ; Yeh, Ta-Chuan 1   VIAFID ORCID Logo  ; Wei-Chou, Chang 3 ; Singh, Ajeet B 4 ; Chin-Bin Yeh 1   VIAFID ORCID Logo  ; Yi-Jen, Hung 5 ; Kuo-Sheng, Hung 6   VIAFID ORCID Logo  ; Hsin-An, Chang 1   VIAFID ORCID Logo 

 Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan; [email protected] (C.-C.H.); [email protected] (Y.-G.W.); [email protected] (T.-C.Y.); [email protected] (C.-B.Y.) 
 Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei 114, Taiwan; [email protected] 
 Department of Radiology, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan; [email protected] 
 IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Deakin University, Geelong, VIC 3220, Australia; [email protected] 
 Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan; [email protected] 
 Center for Precision Medicine and Genomics, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei 114, Taiwan 
First page
1271
Publication year
2024
Publication date
2024
Publisher
MDPI AG
ISSN
1010660X
e-ISSN
16489144
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3098085357
Copyright
© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.