Full text

Turn on search term navigation

© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

African swine fever virus (ASFV) is the causative agent of African swine fever (ASF), a highly infectious and lethal disease of domesticated swine. Outbreaks of ASF have been mostly restricted to the continent of Africa. The outbreaks that have occurred outside of Africa were controlled by extensive depopulation of the domesticated pig population. However, in 2007, an outbreak occurred in the country of Georgia, where ASFV infected wild pigs and quickly spread across eastern Europe. Since the reintroduction of ASF into Europe, variants of the current pandemic strain, ASFV Georgia 2007/01 (ASFV-G), which is classified as Genotype 2 based on p72 sequencing, have been reported in countries within western Europe, Asia, and the island of Hispaniola. Additionally, isolates collected in 2020 confirmed the presence of variants of ASFV-G in Nigeria. Recently, we reported similar variants of ASFV-G collected from domestic pigs suspected of dying of ASF in Ghana in 2022. Here, we retroactively report, based on full-length sequencing, that similar variants were present in Ghana in 2021. The SNP analysis revealed derivatives of ASFV with distinct genetic markers. Furthermore, we identified three full-length ASFV genomes as Genotype 1, indicating that there were two genotypes circulating in proximity during the 2021 ASF outbreaks in Ghana.

Details

Title
A Retrospective Analysis Reveals That the 2021 Outbreaks of African Swine Fever Virus in Ghana Were Caused by Two Distinct Genotypes
Author
Rai, Ayushi 1 ; Spinard, Edward 2   VIAFID ORCID Logo  ; Osei-Bonsu, Jehadi 3 ; Meyers, Amanda 1 ; Dinhobl, Mark 4 ; Vivian O’Donnell 5   VIAFID ORCID Logo  ; Ababio, Patrick T 6 ; Tawiah-Yingar, Daniel 6 ; Arthur, Daniel 6 ; Baah, Daniel 6 ; Ramirez-Medina, Elizabeth 2 ; Espinoza, Nallely 2 ; Valladares, Alyssa 1 ; Faburay, Bonto 7 ; Ambagala, Aruna 8   VIAFID ORCID Logo  ; Odoom, Theophilus 6 ; Borca, Manuel V 2 ; Gladue, Douglas P 2   VIAFID ORCID Logo 

 U.S. Department of Agriculture, Agricultural Research Service, Foreign Animal Disease Research Unit, Plum Island Animal Disease Center, Orient, NY 11957, USA; [email protected] (A.R.); [email protected] (E.S.); [email protected] (A.M.); [email protected] (M.D.); [email protected] (E.R.-M.); [email protected] (N.E.); [email protected] (A.V.); Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN 37830, USA 
 U.S. Department of Agriculture, Agricultural Research Service, Foreign Animal Disease Research Unit, Plum Island Animal Disease Center, Orient, NY 11957, USA; [email protected] (A.R.); [email protected] (E.S.); [email protected] (A.M.); [email protected] (M.D.); [email protected] (E.R.-M.); [email protected] (N.E.); [email protected] (A.V.); U.S. Department of Agriculture, Agricultural Research Service, Foreign Animal Disease Research Unit, National Bio and Agro-Defense Facility, Manhattan, KS 66502, USA 
 Accra Veterinary Laboratory of Veterinary Services Directorate, Accra P.O. Box GA184, Ghana; [email protected] (J.O.-B.); [email protected] (P.T.A.); [email protected] (D.T.-Y.); [email protected] (D.A.); [email protected] (D.B.); [email protected] (T.O.); Department of Liberal Arts & Sciences, University of Illinois at Urbana-Champaign, Champaign, IL 61820, USA 
 U.S. Department of Agriculture, Agricultural Research Service, Foreign Animal Disease Research Unit, Plum Island Animal Disease Center, Orient, NY 11957, USA; [email protected] (A.R.); [email protected] (E.S.); [email protected] (A.M.); [email protected] (M.D.); [email protected] (E.R.-M.); [email protected] (N.E.); [email protected] (A.V.) 
 U.S. Department of Agriculture, Animal and Plant Inspection Service, Plum Island Animal Disease Center, Greenport, NY 11944, USA; [email protected] 
 Accra Veterinary Laboratory of Veterinary Services Directorate, Accra P.O. Box GA184, Ghana; [email protected] (J.O.-B.); [email protected] (P.T.A.); [email protected] (D.T.-Y.); [email protected] (D.A.); [email protected] (D.B.); [email protected] (T.O.) 
 U.S. Department of Agriculture, Animal and Plant Inspection Service, National Bio and Agro-Defense Facility, Greenport, NY 11944, USA; [email protected] 
 National Centre for Foreign Animal Disease, Canadian Food Inspection Agency, Winnipeg, MB R3E 3M4, Canada; [email protected] 
First page
1265
Publication year
2024
Publication date
2024
Publisher
MDPI AG
e-ISSN
19994915
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3098225837
Copyright
© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.