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Abstract
Although prostate cancer is a common occurrence among males, the relationship between existing risk prediction models remains unclear. The objective of this hospital-based retrospective study is to investigate the impact of polygenic risk scores (PRSs) on the incidence and prognosis of prostate cancer in the Han Chinese population. A total of 24,778 male participants including 903 patients with prostate cancer at Taichung Veterans General Hospital were enrolled in the study. PRS was calculated using 269 single nucleotide polymorphisms and their corresponding effect sizes from the polygenic score catalog. The association between PRS and the risk prostate cancer was evaluated using Cox proportional hazards regression model. Among the 24,778 participants, 903 were diagnosed with prostate cancer. The risk of prostate cancer was significantly higher in the highest quartile of PRS distribution compared to the lowest (hazard ratio = 4.770, 95% CI = 3.999–5.689, p < 0.0001), with statistical significance across all age groups. Patients in the highest quartile were diagnosed with prostate cancer at a younger age (66.8 ± 8.3 vs. 69.5 ± 8.8, p = 0.002). Subgroup analysis of patients with localized or stage 4 prostate cancer showed no significant differences in biochemical failure or overall survival. This hospital-based cohort study observed that a higher PRS was associated with increased susceptibility to prostate cancer and younger age of diagnosis. However, PRS was not found to be a significant predictor of disease stage and prognosis. These findings suggest that PRS could serve as a useful tool in prostate cancer risk assessment.
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1 Taichung Veterans General Hospital, Department of Urology, Taichung, Taiwan (GRID:grid.410764.0) (ISNI:0000 0004 0573 0731); National Chung Hsing University, Department of Post-Baccalaureate Medicine, College of Medicine, Taichung, Taiwan (GRID:grid.260542.7) (ISNI:0000 0004 0532 3749); Chung Shan Medical University, Institute of Medicine, Taichung, Taiwan (GRID:grid.411641.7) (ISNI:0000 0004 0532 2041)
2 Taichung Veterans General Hospital, Department of Medical Research, Taichung, Taiwan (GRID:grid.410764.0) (ISNI:0000 0004 0573 0731); Fu Jen Catholic University, Department of Public Health, New Taipei City, Taiwan (GRID:grid.256105.5) (ISNI:0000 0004 1937 1063); National Chung Hsing University, Institute of Genomics and Bioinformatics, Taichung, Taiwan (GRID:grid.260542.7) (ISNI:0000 0004 0532 3749)
3 Taichung Veterans General Hospital, Department of Medical Research, Taichung, Taiwan (GRID:grid.410764.0) (ISNI:0000 0004 0573 0731)
4 Taichung Veterans General Hospital, Department of Urology, Taichung, Taiwan (GRID:grid.410764.0) (ISNI:0000 0004 0573 0731); Chung Shan Medical University, Institute of Medicine, Taichung, Taiwan (GRID:grid.411641.7) (ISNI:0000 0004 0532 2041); National Chi Nan University, Department of Applied Chemistry, Nantou, Taiwan (GRID:grid.412044.7) (ISNI:0000 0001 0511 9228)
5 Taichung Veterans General Hospital, Department of Urology, Taichung, Taiwan (GRID:grid.410764.0) (ISNI:0000 0004 0573 0731); National Chung Hsing University, Department of Post-Baccalaureate Medicine, College of Medicine, Taichung, Taiwan (GRID:grid.260542.7) (ISNI:0000 0004 0532 3749); Chung Shan Medical University, Institute of Medicine, Taichung, Taiwan (GRID:grid.411641.7) (ISNI:0000 0004 0532 2041); Hungkuang University, Department of Medicine and Nursing, Taichung, Taiwan (GRID:grid.411432.1) (ISNI:0000 0004 1770 3722)