Abstract

This article delves into Alzheimer’s disease (AD), a prevalent neurodegenerative condition primarily affecting the elderly. It is characterized by progressive memory and cognitive impairments, severely disrupting daily life. Recent research highlights the potential involvement of microRNAs in the pathogenesis of AD. MicroRNAs (MiRNAs), short non-coding RNAs comprising 20–24 nucleotides, significantly influence gene regulation by hindering translation or promoting degradation of target genes. This review explores the role of specific miRNAs in AD progression, focusing on their impact on β-amyloid (Aβ) peptide accumulation, intracellular aggregation of hyperphosphorylated tau proteins, mitochondrial dysfunction, neuroinflammation, oxidative stress, and the expression of the APOE4 gene. Our insights contribute to understanding AD’s pathology, offering new avenues for identifying diagnostic markers and developing novel therapeutic targets.

Details

Title
MicroRNAs: pioneering regulators in Alzheimer’s disease pathogenesis, diagnosis, and therapy
Author
Li, Yao-Bo 1 ; Fu, Qiang 2 ; Guo, Mei 3 ; Du, Yang 2 ; Chen, Yuewen 4 ; Cheng, Yong 5   VIAFID ORCID Logo 

1  Minzu University of China, Center on Translational Neuroscience, College of Life and Environmental Sciences, Beijing, China (GRID:grid.411077.4) (ISNI:0000 0004 0369 0529) 
2  Minzu University of China, Institute of National Security, Beijing, China (GRID:grid.411077.4) (ISNI:0000 0004 0369 0529) 
3  Minzu University of China, Key Laboratory of Ethnomedicine of Ministry of Education, School of Pharmacy, Beijing, China (GRID:grid.411077.4) (ISNI:0000 0004 0369 0529) 
4  Chinese Academy of Sciences, Shenzhen–Hong Kong Institute of Brain Science—Shenzhen Fundamental Research Institutions, Chinese Academy of Sciences Key Laboratory of Brain Connectome and Manipulation, Shenzhen Key Laboratory of Translational Research for Brain Diseases, The Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Shenzhen, China (GRID:grid.9227.e) (ISNI:0000000119573309); HKUST Shenzhen Research Institute, Guangdong Provincial Key Laboratory of Brain Science, Disease and Drug Development, Shenzhen, China (GRID:grid.495521.e) 
5  Minzu University of China, Center on Translational Neuroscience, College of Life and Environmental Sciences, Beijing, China (GRID:grid.411077.4) (ISNI:0000 0004 0369 0529); Minzu University of China, Institute of National Security, Beijing, China (GRID:grid.411077.4) (ISNI:0000 0004 0369 0529); Minzu University of China, Key Laboratory of Ethnomedicine of Ministry of Education, School of Pharmacy, Beijing, China (GRID:grid.411077.4) (ISNI:0000 0004 0369 0529) 
Pages
367
Publication year
2024
Publication date
2024
Publisher
Nature Publishing Group
e-ISSN
21583188
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41398-024-03075-8
ProQuest document ID
3102573945
Copyright
© The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.