Full text

Turn on search term navigation

© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Boron Neutron Capture Therapy (BNCT) is a cancer treatment which combines tumor-selective boron delivery agents with thermal neutrons in order to selectively eradicate cancer cells. In this work, we focus on the early-stage development of carbohydrate delivery agents for BNCT. In more detail, we expand upon our previous GLUT-targeting approach by synthesizing and evaluating the potential embedded in a representative set of fluorinated carbohydrates bearing a boron cluster. Our findings indicate that these species may have advantages over the boron delivery agents in current clinical use, e.g., significantly improved boron delivery capacity at the cellular level. Simultaneously, the carbohydrate delivery agents were found to bind strongly to plasma proteins, which may be a concern requiring further action before progression to in vivo studies. Altogether, this work brings new insights into factors which need to be accounted for if attempting to develop theranostic agents for BNCT based on carbohydrates in the future.

Details

Title
Towards New Delivery Agents for Boron Neutron Capture Therapy: Synthesis and In Vitro Evaluation of a Set of Fluorinated Carbohydrate Derivatives
Author
Matović, Jelena 1   VIAFID ORCID Logo  ; Järvinen, Juulia 2   VIAFID ORCID Logo  ; Sokka, Iris K 1 ; Imlimthan, Surachet 1 ; Aitio, Olli 3 ; Sarparanta, Mirkka 1   VIAFID ORCID Logo  ; Rautio, Jarkko 2   VIAFID ORCID Logo  ; Ekholm, Filip S 1   VIAFID ORCID Logo 

 Department of Chemistry, University of Helsinki, FI-00014 Helsinki, Finland; [email protected] (J.M.); [email protected] (I.K.S.); [email protected] (S.I.); [email protected] (M.S.) 
 School of Pharmacy, University of Eastern Finland, FI-70211 Kuopio, Finland; [email protected] (J.J.); [email protected] (J.R.) 
 Glykos Finland Ltd., FI-00790 Helsinki, Finland; [email protected] 
First page
4263
Publication year
2024
Publication date
2024
Publisher
MDPI AG
e-ISSN
14203049
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3103959924
Copyright
© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.