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© 2024. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

The Hispanic/Latino population is one of the largest and most diverse ethnoracial groups in the United States at high risk for dementia. We examined cognitive constructs and associations with subsequent hippocampal volume (HV) and white matter hyperintensity volume (WMHV). Participants were from the Hispanic Community Health Study/Study of Latinos–Magnetic Resonance Imaging Study (= 2029). We examined confirmatory factor analysis and longitudinal invariance using neurocognitive scores at Visits 1 (2008–2011) and 2 (2014–2018) and path analyses. We obtained a longitudinally invariant two‐factor episodic memory (EM) and working memory (WM) construct. Lower EM profile at both visits was associated with greater WMHV and smaller HV at Visit 2. Lower WM profile at both visits was associated with larger WMHV and smaller HV at Visit 2. Neurocognitive profiles were associated with subsequent neurodegeneration in a sample of Hispanics/Latinos. Identifying neurocognitive risk profiles may lead to early detection and intervention, and significantly impact the course of neurodegeneration.

Highlights

Cognitive profiles predict brain integrity up to 10 years later. We observed two‐factor latent memory constructs and longitudinal invariance. These findings were observed in a Hispanic/Latino cohort.

Details

Title
Neurocognitive profiles are associated with subsequent brain integrity in a sample of Hispanics/Latinos: Findings from the SOL‐INCA‐MRI study (HCHS/SOL)
Author
Sapkota, Shraddha 1 ; Maillard, Pauline 1 ; Stickel, Ariana M. 2 ; Tarraf, Wassim 3 ; Gonzalez, Kevin A. 4 ; Ivanovic, Vladimir 5 ; Morlett‐Paredes, Alejandra 4 ; Cai, Jianwen 6 ; Isasi, Carmen R. 7 ; Lipton, Richard B. 7 ; Daviglus, Martha 8 ; Testai, Fernando Daniel 8 ; Lamar, Melissa 9 ; Gallo, Linda C. 2 ; Talavera, Gregory A. 2 ; Agudelo, Christian 10 ; Ramos, Alberto R. 10 ; González, Hector M. 4 ; DeCarli, Charles 1 

 Department of Neurology, University of California, Davis, California, USA 
 San Diego State University, San Diego, California, USA 
 Wayne State University, Detroit, Michigan, USA 
 University of California, San Diego, California, USA 
 Medical College of Wisconsin, Milwaukee, Wisconsin, USA 
 The University of North Carolina, Chapel Hill, North Carolina, USA 
 Albert Einstein College of Medicine, Bronx, New York, USA 
 University of Illinois, Chicago, Illinois, USA 
 Rush University, Chicago, Illinois, USA 
10  University of Miami, Coral Gables, Florida, USA 
Section
RESEARCH ARTICLE
Publication year
2024
Publication date
Jul 1, 2024
Publisher
John Wiley & Sons, Inc.
e-ISSN
23528729
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3109590329
Copyright
© 2024. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.