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© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Systematic inflammatory response syndrome (SIRS) and the accompanying sepsis pose a huge threat to human health worldwide. Heparin is a part of the standard supportive care for the disease. However, the molecular mechanism is not fully understood yet, and the potential signaling pathways that play key roles have not yet been elucidated. In this paper, the main findings regarding the molecular mechanisms associated with the beneficial effects of heparin, including inhibiting HMGB-1-driven inflammation reactions, histone-induced toxicity, thrombo-inflammatory response control and the new emerging mechanisms are concluded. To set up the link between the preclinical research and the clinical effects, the outcomes of the clinical trials are summarized. Then, the structure and function relationship of heparin is discussed. By providing an updated analysis of the above results, the paper highlights the feasibility of heparin as a possible alternative for sepsis prophylaxis and therapy.

Details

Title
The Preventive and Therapeutic Effects of Acute and Severe Inflammatory Disorders with Heparin and Heparinoid
Author
Song, Ying 1 ; Wu, Yuxiang 1 ; Ding, Fangfang 1 ; Li, Shuo 2 ; Shen, Yaojia 1 ; Yang, Bingyan 1 ; Tang, Xinran 1 ; Ren, Lige 3 ; Deng, Lirong 3 ; Jin, Xuewen 3 ; Yishu Yan 1 

 School of Life Sciences and Health Engineering, Jiangnan University, Wuxi 214122, China[email protected] (Y.W.); [email protected] (X.T.) 
 Medi-X Pingshan, Southern University of Science and Technology, Shenzhen 518118, China 
 Shenzhen Hepalink Pharmaceutical Group Co., Ltd., Shenzhen 518057, China 
First page
1078
Publication year
2024
Publication date
2024
Publisher
MDPI AG
e-ISSN
2218273X
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3110378887
Copyright
© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.