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© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Regenerating Family Member 3 Alpha (REG3A) is an antimicrobial protein secreted by the intestine and pancreas with additional immunomodulatory properties. Previously, we published that REG3A expression in ischemic stroke patient systemic blood, during mechanical thrombectomy (MT), is significantly associated with inflammatory cytokines and patient function on admission. This paper, however, did not investigate post-acute death rates. Therefore, we investigated plasma REG3A protein expression, during MT, in patients (n = 141) that survived or died within the end of the follow-up after MT. Subjects who died had significantly higher systemic plasma REG3A levels at the time of MT compared to survivors (p = 0.001). Age, sex, time from last known normal, and admission NIHSS were included as predictors to control for confounding variables and were all examined to determine their association in patient mortality. Logistic regression was used to demonstrate that higher odds of death were associated with increased REG3A levels (p = 0.002). REG3A demonstrated acceptable discrimination (AUC (95% CI): 0.669 (0.566–0.772) in predicting mortality. The overall model with age, sex, time from last known normal, and admission NIHSS discriminated well between survivors and those who died (AUC (95% CI): 0.784 (0.703–0.864)). In conclusion, REG3A could be promising as a biomarker to prognosticate stroke outcomes and stratify high-risk groups following acute ischemic stroke.

Details

Title
Regenerating Family Member 3 Alpha Is Predictive of Mortality Following Emergent Large Vessel Occlusion
Author
Sands, Madison 1   VIAFID ORCID Logo  ; McLouth, Christopher J 2   VIAFID ORCID Logo  ; Frank, Jacqueline A 3 ; Benton Maglinger 4   VIAFID ORCID Logo  ; Millson, Nathan 5 ; Al-Kawaz, Mais N 5 ; Pahwa, Shivani 6 ; DornbosIII, David L 7 ; Lukins, Douglas E 8 ; Trout, Amanda L 7   VIAFID ORCID Logo  ; Stowe, Ann M 9   VIAFID ORCID Logo  ; Fraser, Justin F 10 ; Pennypacker, Keith R 9 

 Department of Neurology, University of Kentucky, Lexington, KY 40506, USA; [email protected] (M.S.); [email protected] (C.J.M.); [email protected] (J.A.F.); [email protected] (D.E.L.); [email protected] (A.M.S.); [email protected] (J.F.F.) 
 Department of Neurology, University of Kentucky, Lexington, KY 40506, USA; [email protected] (M.S.); [email protected] (C.J.M.); [email protected] (J.A.F.); [email protected] (D.E.L.); [email protected] (A.M.S.); [email protected] (J.F.F.); Department of Biostatistics, University of Kentucky, Lexington, KY 40506, USA 
 Department of Neurology, University of Kentucky, Lexington, KY 40506, USA; [email protected] (M.S.); [email protected] (C.J.M.); [email protected] (J.A.F.); [email protected] (D.E.L.); [email protected] (A.M.S.); [email protected] (J.F.F.); Center for Advanced Translational Stroke Science, University of Kentucky, Lexington, KY 40506, USA; [email protected] (D.L.D.III); [email protected] (A.L.T.) 
 BrainCo, Inc., Somerville, MA 02143, USA; [email protected] 
 Department of Neurosurgery, University of Kentucky, Lexington, KY 40506, USA; [email protected] (N.M.); [email protected] (M.N.A.-K.); [email protected] (S.P.) 
 Department of Neurosurgery, University of Kentucky, Lexington, KY 40506, USA; [email protected] (N.M.); [email protected] (M.N.A.-K.); [email protected] (S.P.); Department of Radiology, University of Kentucky, Lexington, KY 40506, USA 
 Center for Advanced Translational Stroke Science, University of Kentucky, Lexington, KY 40506, USA; [email protected] (D.L.D.III); [email protected] (A.L.T.); Department of Neurosurgery, University of Kentucky, Lexington, KY 40506, USA; [email protected] (N.M.); [email protected] (M.N.A.-K.); [email protected] (S.P.) 
 Department of Neurology, University of Kentucky, Lexington, KY 40506, USA; [email protected] (M.S.); [email protected] (C.J.M.); [email protected] (J.A.F.); [email protected] (D.E.L.); [email protected] (A.M.S.); [email protected] (J.F.F.); Department of Radiology, University of Kentucky, Lexington, KY 40506, USA 
 Department of Neurology, University of Kentucky, Lexington, KY 40506, USA; [email protected] (M.S.); [email protected] (C.J.M.); [email protected] (J.A.F.); [email protected] (D.E.L.); [email protected] (A.M.S.); [email protected] (J.F.F.); Center for Advanced Translational Stroke Science, University of Kentucky, Lexington, KY 40506, USA; [email protected] (D.L.D.III); [email protected] (A.L.T.); Department of Neuroscience, University of Kentucky, Lexington, KY 40506, USA 
10  Department of Neurology, University of Kentucky, Lexington, KY 40506, USA; [email protected] (M.S.); [email protected] (C.J.M.); [email protected] (J.A.F.); [email protected] (D.E.L.); [email protected] (A.M.S.); [email protected] (J.F.F.); Center for Advanced Translational Stroke Science, University of Kentucky, Lexington, KY 40506, USA; [email protected] (D.L.D.III); [email protected] (A.L.T.); Department of Neurosurgery, University of Kentucky, Lexington, KY 40506, USA; [email protected] (N.M.); [email protected] (M.N.A.-K.); [email protected] (S.P.); Department of Radiology, University of Kentucky, Lexington, KY 40506, USA; Department of Neuroscience, University of Kentucky, Lexington, KY 40506, USA; Department of Otolaryngology, University of Kentucky, Lexington, KY 40506, USA 
First page
9968
Publication year
2024
Publication date
2024
Publisher
MDPI AG
ISSN
16616596
e-ISSN
14220067
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3110530750
Copyright
© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.