Full text

Turn on search term navigation

© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Cytopenias or coagulation deficiencies can occur in people living with HIV (PLWH). The severity of these disorders is influenced by the low levels of CD4+ lymphocytes, viral load, and the stage of viral infection. The aim of our retrospective observational study was to determine the frequency of cytopenias and coagulation deficiencies in PLWH as well as the need for replacement therapy with blood products. We sought to determine whether there is an association between severe anemia or thrombocytopenia (requiring replacement therapy) and CD4+T lymphocyte levels. All 29 patients were critically ill, with 27 out of 29 (93%) in advanced stages of HIV disease and 23 out of 29 (79%) having CD4+ lymphocyte counts below 200 cells/microL. Most patients were either late presenters (45%) or had been lost to follow-up (41%). In addition to HIV infection, various conditions that could alter hematologic parameters were associated, including co-infections with hepatitis viruses, tuberculosis at various sites, malignant diseases, sepsis, SARS-CoV-2 infection, or other opportunistic infections. No significant correlation was found between severe anemia or severe thrombocytopenia or coagulation deficiencies and the CD4+T lymphocyte count. Our data suggest that these hematological disorders in patients with advanced HIV infection are more likely to be associated comorbidities rather than the HIV infection per se.

Details

Title
Replacement Therapy with Blood Products in People Living with HIV
Author
Olariu, Mihaela Cristina 1   VIAFID ORCID Logo  ; Iancu, Mihaela Adela 2   VIAFID ORCID Logo  ; Olariu, Mihai Hristu 3 ; Aramă, Victoria 1 ; Simoiu, Mădălina 1 ; Cruceru, Miruna Maria 3 ; Barbu, Ecaterina Constanta 4   VIAFID ORCID Logo  ; Balanescu, Paul 5 ; Lazar, Mihai 6 

 Department of Infectious Diseases, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania; [email protected] (M.C.O.); [email protected] (V.A.); [email protected] (M.S.); “Matei Bals” National Institute of Infectious Diseases, 021105 Bucharest, Romania; [email protected] (M.H.O.); [email protected] (M.M.C.); [email protected] (M.L.) 
 Department of Internal, Family and Occupational Medicine, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania; [email protected] 
 “Matei Bals” National Institute of Infectious Diseases, 021105 Bucharest, Romania; [email protected] (M.H.O.); [email protected] (M.M.C.); [email protected] (M.L.) 
 Department of Pathophysiology, Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania; [email protected] 
 Department of Internal, Family and Occupational Medicine, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania; [email protected]; Romania Clinical Research Unit RECIF (Reseau d’Epidemiologie Clinique International Francophone), 020125 Bucharest, Romania 
 “Matei Bals” National Institute of Infectious Diseases, 021105 Bucharest, Romania; [email protected] (M.H.O.); [email protected] (M.M.C.); [email protected] (M.L.); Department of Pathophysiology, Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania; [email protected] 
First page
213
Publication year
2024
Publication date
2024
Publisher
MDPI AG
e-ISSN
24146366
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3110698398
Copyright
© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.