Abstract

Proximity barcoding assay, a high-throughput method for single-exosome analysis, was employed to profile surface proteins on individual exosomes of SCZ patients. This analysis identified five differentially expressed proteins (DEPs) between SCZ patients and healthy controls (HC) and six DEPs between antipsychotic responders and non-responders. Furthermore, two exosome clusters were found to be associated with SCZ, and certain DEPs were correlated with cognitive functions.

Details

Title
Profiling expressing features of surface proteins on single-exosome in first-episode Schizophrenia patients: a preliminary study
Author
Zhang, Sijie 1 ; Liao, Aijun 1 ; Wang, Yujue 1 ; Liu, Qian 1 ; Ouyang, Lijun 1 ; Peng, Huiqing 1 ; Yuan, Liu 1 ; Zhao, Linlin 1 ; Yang, Xinbo 1 ; Chen, Xiaogang 2   VIAFID ORCID Logo  ; He, Ying 2 ; Li, Zongchang 2 

1  The Second Xiangya Hospital of Central South University, Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, Changsha, China (GRID:grid.452708.c) (ISNI:0000 0004 1803 0208) 
2  The Second Xiangya Hospital of Central South University, Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, Changsha, China (GRID:grid.452708.c) (ISNI:0000 0004 1803 0208); Central South University, China National Technology Institute on Mental Disorders & Hunan Key, Laboratory of Psychiatry and Mental Health, Mental Health Institute of the Second Xiangya Hospital, Changsha, China (GRID:grid.216417.7) (ISNI:0000 0001 0379 7164) 
Pages
84
Publication year
2024
Publication date
2024
Publisher
Nature Publishing Group
e-ISSN
2334265X
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41537-024-00510-z
ProQuest document ID
3111349861
Copyright
© The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.