It appears you don't have support to open PDFs in this web browser. To view this file, Open with your PDF reader
Abstract
Effective antihypertensive therapy is essential for achieving optimal blood pressure (BP) control and reducing cardiovascular events. This double-blind, multicenter, randomized trial aimed to compare the antihypertensive efficacy and safety of a combination of amlodipine (AML) and candesartan cilexetil (CC) versus AML monotherapy in patients with essential hypertension (HTN). After a 4-week run-in period with AML 5 mg, patients whose HTN remained uncontrolled (diastolic BP [DBP]) ≥ 90 mmHg and < 120 mmHg) were randomized to receive either AML + CC or AML alone for 8 weeks. Efficacy was assessed by measuring changes in DBP and systolic BP (SBP). The primary safety measure was the incidence of adverse events (AEs). A total of 174 participants were included in the efficacy analysis. After 8 weeks, DBP decreased by -9.92 ± 0.86 mmHg in the AML + CC arm and - 2.08 ± 0.86 mmHg in the AML arm (p < 0.0001). SBP decreased by -14.27 ± 1.39 mmHg in the AML + CC arm versus - 2.77 ± 1.39 mmHg in the AML arm (p < 0.0001). AEs occurred in 11.24% of the AML + CC group and 5.62% of the AML group (p = 0.1773). AML + CC combination therapy demonstrated superior efficacy with good tolerance, making it a promising option for patients with inadequately controlled hypertension on amlodipine alone.
You have requested "on-the-fly" machine translation of selected content from our databases. This functionality is provided solely for your convenience and is in no way intended to replace human translation. Show full disclaimer
Neither ProQuest nor its licensors make any representations or warranties with respect to the translations. The translations are automatically generated "AS IS" and "AS AVAILABLE" and are not retained in our systems. PROQUEST AND ITS LICENSORS SPECIFICALLY DISCLAIM ANY AND ALL EXPRESS OR IMPLIED WARRANTIES, INCLUDING WITHOUT LIMITATION, ANY WARRANTIES FOR AVAILABILITY, ACCURACY, TIMELINESS, COMPLETENESS, NON-INFRINGMENT, MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. Your use of the translations is subject to all use restrictions contained in your Electronic Products License Agreement and by using the translation functionality you agree to forgo any and all claims against ProQuest or its licensors for your use of the translation functionality and any output derived there from. Hide full disclaimer
Details
1 Ajou University School of Medicine, Department of Cardiology, Suwon, Republic of Korea (GRID:grid.251916.8) (ISNI:0000 0004 0532 3933)
2 Seoul Medical Center, Department of Internal Medicine, Seoul, Republic of Korea (GRID:grid.415520.7) (ISNI:0000 0004 0642 340X)
3 University of Ulsan College of Medicine, Division of Cardiology, Department of Internal Medicine, Asan Medical Center, Seoul, Republic of Korea (GRID:grid.267370.7) (ISNI:0000 0004 0533 4667)
4 Seoul Medical Center, Department of Cardiology, Seoul, Republic of Korea (GRID:grid.415520.7) (ISNI:0000 0004 0642 340X)
5 Soonchunhyang University Hospital, Division of Cardiology, Department of Internal Medicine, Seoul, Republic of Korea (GRID:grid.412678.e) (ISNI:0000 0004 0634 1623)
6 The Catholic University of Korea, Division of Cardiology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, Seoul, Republic of Korea (GRID:grid.411947.e) (ISNI:0000 0004 0470 4224)
7 Korea University Guro Hospital, Division of Cardiology, Seoul, Republic of Korea (GRID:grid.411134.2) (ISNI:0000 0004 0474 0479)
8 Inje University College of Medicine, Division of Cardiology, Department of Internal Medicine, Haeundae Paik Hospital, Busan, Republic of Korea (GRID:grid.411612.1) (ISNI:0000 0004 0470 5112)
9 Chonnam National University Hospital, Department of Cardiology, Gwangju, Republic of Korea (GRID:grid.411597.f) (ISNI:0000 0004 0647 2471)
10 Sungkyunkwan University School of Medicine, Division of Cardiology, Department of Internal Medicine, Kangbuk Samsung Hospital, Seoul, Republic of Korea (GRID:grid.264381.a) (ISNI:0000 0001 2181 989X)
11 Seoul National University Bundang Hospital, Division of Cardiology, Department of Internal Medicine, Seongnam, Republic of Korea (GRID:grid.412480.b) (ISNI:0000 0004 0647 3378)
12 Yeungnam University Hospital, Division of Cardiology, Department of Internal Medicine, Daegu, Republic of Korea (GRID:grid.413028.c) (ISNI:0000 0001 0674 4447)
13 Inje University Busan Paik Hospital, Division of Cardiology, Department of Internal Medicine, Busan, Republic of Korea (GRID:grid.411625.5) (ISNI:0000 0004 0647 1102)
14 Hallym University Sacred Heart Hospital, Division of Cardiology, Anyang, Republic of Korea (GRID:grid.488421.3) (ISNI:0000 0004 0415 4154)