Abstract

Patients with diabetes mellitus (DM) are at risk of developing frailty, but studies rarely addressed risk factors for frailty worsening. We investigated whether blood pressure (BP)-lowering agents influenced such risk in these patients. Adults with type 2 DM were identified from National Taiwan University Hospital, with the primary outcome, the worsening of frailty by ≧1 score increase of FRAIL scale determined. We used the Cox proportional hazards analysis to derive the risk of worsening frailty associated with BP-lowering agents. Among 41,440 patients with DM, 27.4% developed worsening frailty after 4.09 years of follow-up. Cox regression revealed that diuretics (hazard ratio (HR) 1.12, 95% confidence interval (CI) 1.06–1.18) and α-blocker (HR 1.14, 95% CI 1.06–1.23) users had a significantly higher risk of worsening frailty than non-users, whereas the risk was lower among β-blocker users (HR 0.93, 95% CI 0.88–0.98). It would be therefore prudent to weigh the advantages and disadvantages of using specific BP-lowering agent classes.

Details

Title
The impact of blood pressure lowering agents on the risk of worsening frailty among patients with diabetes mellitus: a cohort study
Author
Wang, Jui 1 ; Lee, Szu-Ying 2 ; Chao, Chia-Ter 3   VIAFID ORCID Logo  ; Huang, Jenq-Wen 4 ; Chien, Kuo-Liong 5 

1  National Taiwan University, Institute of Epidemiology and Preventive Medicine, College of Public Health, Taipei, Taiwan (GRID:grid.19188.39) (ISNI:0000 0004 0546 0241); National Taiwan University, Health Data Research Center, Taipei, Taiwan (GRID:grid.19188.39) (ISNI:0000 0004 0546 0241) 
2  National Taiwan University Hospital Yunlin branch, Division of Nephrology, Department of Internal Medicine, Yunlin County, Taiwan (GRID:grid.412094.a) (ISNI:0000 0004 0572 7815) 
3  National Taiwan University Hospital and National Taiwan University College of Medicine, Division of Nephrology, Department of Internal Medicine, Taipei, Taiwan (GRID:grid.19188.39) (ISNI:0000 0004 0546 0241); National Taiwan University College of Medicine, Graduate Institute of Medical Education and Bioethics, Taipei, Taiwan (GRID:grid.19188.39) (ISNI:0000 0004 0546 0241); National Taiwan University College of Medicine, Graduate Institute of Toxicology, Taipei, Taiwan (GRID:grid.19188.39) (ISNI:0000 0004 0546 0241); Min-Sheng General Hospital, Division of Nephrology, Department of Internal Medicine, Taoyuan City, Taiwan (GRID:grid.415675.4) (ISNI:0000 0004 0572 8359) 
4  National Taiwan University Hospital and National Taiwan University College of Medicine, Division of Nephrology, Department of Internal Medicine, Taipei, Taiwan (GRID:grid.19188.39) (ISNI:0000 0004 0546 0241) 
5  National Taiwan University, Institute of Epidemiology and Preventive Medicine, College of Public Health, Taipei, Taiwan (GRID:grid.19188.39) (ISNI:0000 0004 0546 0241) 
Pages
44
Publication year
2024
Publication date
2024
Publisher
Nature Publishing Group
e-ISSN
20563973
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41514-024-00173-1
ProQuest document ID
3113908605
Copyright
© The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.