Abstract

A novel approach was adopted to synthesize size-controlled magnetite nanoparticles (MNPs) coated with different molecular weights of polyethylene glycol (PEG), like PEG 750, PEG 2000, and PEG 5000. The drug release kinetics of curcumin (CPMNPs) loaded PEGylated samples were studied. Different techniques used to characterize nanoparticles, like transmission electron microscopy (TEM), x-ray diffraction (XRD) analysis, Fourier transform infrared (FTIR) spectroscopy, and thermogravimetric analysis (TGA). The in-vitro studies of curcumin from CPMNPs samples observed a sustained release through kinetics studies from the PMNPs that followed a pseudo-second order reaction. MNPs functionalized with different molecular weights of PEG to make the MNPS biocompatible; moreover, the role of PEG on sustained release of curcumin was also investigated. It was concluded that the particles synthesized at pH-10 coated with PEG of molecular weight 750 exhibited the highest sustained release efficiency of curcumin, i.e., about 98.8%.

Details

Title
Fabrication and characterization of PEGylated magnetite nanoparticles for sustained curcumin release: in-vitro study
Author
Khan, Basharat 1 ; Nawaz, Mohsan 2 ; Waseem, Muhammad 3   VIAFID ORCID Logo  ; Nasir Shahzad 4 ; Ahad Amer Alsaiari 5 ; Razzokov, Jamoliddin 6   VIAFID ORCID Logo  ; Haq, Sirajul 7   VIAFID ORCID Logo 

1  Department of Chemistry, Hazara University , Mansehra, Pakistan; Department of Chemistry, Abbottabad University of Science and Technology , Pakistan 
2  Department of Chemistry, Hazara University , Mansehra, Pakistan 
3  Department of Chemistry, COMSATS University Islamabad , Islamabad, Pakistan 
4  Department of Chemistry, INHA University , Republic of Korea 
5  Department of Clinical Laboratory Science, College of Applied Medical Science, Taif University , Taif, Saudi Arabia 
6  Institute of Fundamental and Applied Research, National Research University TIIAME , Kori Niyoziy 39, 100000 Tashkent, Uzbekistan; Department of Natural Sciences, Shakhrisabz State Pedagogical Institute , Shakhrisabz street 10, Kashkadarya 181301, Uzbekistan; Department of Biotechnology, Tashkent State Technical University , Universitet 2, Tashkent 100095, Uzbekistan 
7  Department of Chemistry, University of Azad Jammu and Kashmir , Muzaffarabad 13100, Pakistan † 
First page
105007
Publication year
2024
Publication date
Oct 2024
Publisher
IOP Publishing
e-ISSN
20531591
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1088/2053-1591/ad8398
ProQuest document ID
3117061601
Copyright
© 2024 The Author(s). Published by IOP Publishing Ltd. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.