Abstract

The ability of serum biomarkers to predict the prognosis and response to deep-brain stimulation (DBS) therapy in Parkinson’s disease (PD) patients is promising. Here, we showed that NfL differed between healthy individuals and PD patients and that changes in NfL, GFAP, and BDNF occurred only transiently after DBS surgery. Therefore, subthalamic stimulation does not promote neurodegeneration, and these biomarkers do not serve as clinical improvement endpoints in PD DBS patients.

Details

Title
Significance of neurodegeneration and neuroplasticity serum biomarkers in Parkinson’s disease patients treated with subthalamic stimulation
Author
Sanmartino, Florencia 1   VIAFID ORCID Logo  ; Cano-Cano, Fátima 2   VIAFID ORCID Logo  ; Rashid-López, Raúl 3 ; Cruz-Gómez, Álvaro Javier 4 ; Lozano-Soto, Elena 5 ; Macías-García, Paloma 5 ; Sánchez-Fernández, Francisco L. 5 ; López-Sosa, Fernando 5 ; Gómez-Jaramillo, Laura 2 ; Riqué-Dormido, Jesús 6 ; Escamilla-Sevilla, Francisco 7   VIAFID ORCID Logo  ; Espinosa-Rosso, Raúl 8 ; González-Rosa, Javier J. 4   VIAFID ORCID Logo 

1  Institute of Biomedical Research Cadiz (INiBICA), Cadiz, Spain; University of Cadiz, Cadiz, Spain (GRID:grid.7759.c) (ISNI:0000 0001 0358 0096) 
2  Institute of Biomedical Research Cadiz (INiBICA), Cadiz, Spain (GRID:grid.7759.c) 
3  Institute of Biomedical Research Cadiz (INiBICA), Cadiz, Spain (GRID:grid.7759.c); Puerta del Mar University Hospital, Neurology Department, Cadiz, Spain (GRID:grid.411342.1) (ISNI:0000 0004 1771 1175) 
4  Institute of Biomedical Research Cadiz (INiBICA), Cadiz, Spain (GRID:grid.411342.1); University of Cadiz, Cadiz, Spain (GRID:grid.7759.c) (ISNI:0000 0001 0358 0096) 
5  Institute of Biomedical Research Cadiz (INiBICA), Cadiz, Spain (GRID:grid.7759.c); University of Cadiz, Cadiz, Spain (GRID:grid.7759.c) (ISNI:0000 0001 0358 0096) 
6  Institute of Biomedical Research Cadiz (INiBICA), Cadiz, Spain (GRID:grid.7759.c); Puerta del Mar University Hospital, Neurosurgery Department, Cadiz, Spain (GRID:grid.411342.1) (ISNI:0000 0004 1771 1175) 
7  Institute of Bio-Health Research (IBS. Granada), Department of Neurology, Virgen de las Nieves University Hospital, Granada, Spain (GRID:grid.507088.2) 
8  Institute of Biomedical Research Cadiz (INiBICA), Cadiz, Spain (GRID:grid.507088.2); Puerta del Mar University Hospital, Neurology Department, Cadiz, Spain (GRID:grid.411342.1) (ISNI:0000 0004 1771 1175) 
Pages
197
Publication year
2024
Publication date
2024
Publisher
Nature Publishing Group
e-ISSN
23738057
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41531-024-00808-w
ProQuest document ID
3120212309
Copyright
© The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.