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Abstract
To investigate the relationship between Leisure time physical activity (LTPA) patterns and PhenoAgeAccel in patients with Type 2 diabetes (T2D), emphasizing the role of regular LTPA in mitigating biological aging. This study utilized data from the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018, including 4,134 adults with T2D. Multivariable linear regression models and restricted cubic spline (RCS) methods were employed to assess the relationship between LTPA and Phenotypic age acceleration (PhenoAgeAccel), with segmented likelihood ratio tests to detect nonlinear thresholds. Stratified regression and interaction tests were conducted for robust analysis. Compared to individuals with no LTPA patterns, those with regular LTPA patterns had significantly lower PhenoAgeAccel scores (β = -1.164, 95% CI: -1.651 to -0.677, P < 0.0001), while the “Weekend Warrior” and “Inactive-LTPA” patterns showed no significant effects. A nonlinear threshold effect was identified; below 594.57 min of weekly LTPA, there was a significant negative correlation (β = -0.002, 95% CI: -0.003 to -0.001, P = 0.000), with gender-specific effects present. Regular LTPA significantly reduces phenotypic age acceleration in T2D patients, with a nonlinear threshold effect indicating that moderate physical activity is most beneficial. These findings highlight the necessity of personalized physical activity recommendations and provide evidence for public health strategies to promote healthy aging in T2D patients.
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Details
1 Beijing Sport University, Department of Exercise Physiology, Beijing, China (GRID:grid.411614.7) (ISNI:0000 0001 2223 5394)
2 China University of Geosciences in Beijing, Sport Department, Beijing, China (GRID:grid.162107.3) (ISNI:0000 0001 2156 409X)
3 Ordos Sports Vocational School, Research Medical Center, Ordos, China (GRID:grid.162107.3)
4 Juntendo University, Graduate School of Health and Sports Science, Inzai, Japan (GRID:grid.258269.2) (ISNI:0000 0004 1762 2738)
5 Chinese Table Tennis Association, Beijing, China (GRID:grid.258269.2)
6 Chinese Swimming Academy, Beijing Sport University, Beijing, China (GRID:grid.411614.7) (ISNI:0000 0001 2223 5394)