Abstract

Sleep difficulties affect up to 98% of Parkinson’s disease (PD) patients and are often not well treated. How globus pallidus internus (GPi)-DBS could help is less understood. We retrospectively analyzed sleep outcomes in 32 PD patients after GPi-DBS with a two-year follow-up. We observed high heterogeneity in sleep response to pallidal stimulation: 16 patients showed clinically meaningful improvement, 9 had minor changes, and 7 experienced worsened sleep quality, with no overall significant change on the Parkinson’s Disease Sleep Scale-2 (P = 0.19). Further analysis revealed that stimulation of the left sensorimotor GPi was significantly associated with sleep improvement. Fiber tracts from the left sensorimotor GPi to the bilateral sensorimotor cortex, right GPi, brainstem, and bilateral cerebellum were linked to better sleep, while projections to the left hippocampus correlated with worsened sleep. These findings may guide personalized GPi-DBS lead placement to optimize sleep outcomes in PD.

Details

Title
The effect of pallidal stimulation on sleep outcomes and related brain connectometries in Parkinson’s disease
Author
Zheng, Zhaoting 1   VIAFID ORCID Logo  ; Liu, Defeng 1   VIAFID ORCID Logo  ; Fan, Houyou 1 ; Xie, Hutao 1 ; Zhang, Quan 1 ; Qin, Guofan 1 ; Jiang, Yin 2   VIAFID ORCID Logo  ; Meng, Fangang 1 ; Yin, Zixiao 1   VIAFID ORCID Logo  ; Yang, Anchao 1   VIAFID ORCID Logo  ; Zhang, Jianguo 1   VIAFID ORCID Logo 

1  Capital Medical University, Department of Neurosurgery, Beijing Tiantan Hospital, Beijing, China (GRID:grid.24696.3f) (ISNI:0000 0004 0369 153X) 
2  Beijing Key Laboratory of Neurostimulation, Beijing, China (GRID:grid.413259.8) (ISNI:0000 0004 0632 3337) 
Pages
212
Publication year
2024
Publication date
2024
Publisher
Nature Publishing Group
e-ISSN
23738057
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41531-024-00800-4
ProQuest document ID
3123927748
Copyright
© The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.