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© 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

ABSTRACT

Background

Cardiac troponin I, a particular biomarker, is released into the bloodstream in response to myocardial injury.

Objectives

To evaluate perioperative changes in high‐sensitivity cardiac troponin I (hs‐cTnI) concentration during ovariohysterectomy in cats undergoing three different anaesthesia protocols.

Methods

 Twenty‐one female mixed‐breed cats owned by clients aged (2.2 ± 0.7 years) and weight (3.2 ± 0.5 kg) were included in our study. The cats were divided into three groups: propofol–isoflurane (PI) group (n = 7), xylazine–ketamine (XK) group (n = 7) and xylazine–isoflurane (XI) group (n = 7). After pre‐anaesthetic propofol (6 mg/kg IV) was administered to cats in Group PI, a mask was placed, and anaesthesia was maintained with 3.0% isoflurane in oxygen. Cats in Group XK underwent general anesthetization with xylazine hydrochloride (2 mg/kg IM) and, 10 min later, ketamine hydrochloride (10 mg/kg IM). Cats in Group XI were administered xylazine hydrochloride (2 mg/kg IM), and then anaesthesia (3.0% isoflurane and oxygen) was continued with a mask. Blood samples were collected from all cats; preoperatively and postoperatively at 0 and 12 h (Pre‐, Post‐0 h and Post‐12 h, respectively). Serum hs‐cTnI concentrations were measured with the Advia Centaur TnI‐Ultra.

Results

In all 21 cats, hs‐cTnI concentration increased at Post‐0 h and 12 h measurement points compared to Pre‐. In the XK group, hs‐cTnI concentrations exhibited a significant increase at the Post‐0 h (51.30 ng/L) and Post‐12 h (157.70 ng/L) time points compared to Pre‐ (6.70 ng/L) (p < 0.05).

Conclusions

The XK group increased the concentration of hs‐cTnI more than other protocols. In the PI group, the increase in hs‐cTnI concentrations at Post‐0 and 12 h increased less than the other two groups (p < 0.05). The PI group was found to induce less myocardial damage.

Details

Title
Perioperative Change of High‐Sensitive Cardiac Troponin I Concentration in Cats According to Three Different Anaesthesia Protocols
Author
Safak, Tarik 1   VIAFID ORCID Logo  ; Yılmaz‐Koç, Oznur 2   VIAFID ORCID Logo  ; Karakaya‐Bilen, Ebru 3 

 Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, Kastamonu University, Kastamonu, Türkiye 
 Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, Siirt University, Siirt, Türkiye 
 Department of Obstetrics and Gynecology, Faculty of Ceyhan Veterinary Medicine, Cukurova University, Adana, Türkiye 
Section
ORIGINAL ARTICLE
Publication year
2024
Publication date
Nov 1, 2024
Publisher
John Wiley & Sons, Inc.
e-ISSN
20531095
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3127514868
Copyright
© 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.