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© 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Hydrogels are distinguished by their exceptional ability to absorb and retain large volumes of water within their complex three‐dimensional polymer networks, which is advantageous for the development of intraocular lenses (IOLs). Their innate hydrophilicity offers an optimal substrate for the fabrication of IOLs that simulate the natural lens' accommodation, thereby reducing irritation and facilitating healing after surgery. The swelling and water retention characteristics of hydrogels contribute to their notable biocompatibility and versatile mechanical properties. However, the clinical application of hydrogels faces challenges, including managing potential adverse postimplantation effects. Rigorous research is essential to ascertain the safety and effectiveness of hydrogels. This review systematically examines the prospects and constraints of hydrogels as innovative materials for IOLs. Our comprehensive analysis examines their inherent properties, various classification strategies, cross‐linking processes, and sensitivity to external stimuli. Additionally, we thoroughly evaluate their interactions with ocular tissues, underscoring the potential for hydrogels to be refined into seamless and biologically integrated visual aids. We also discuss the anticipated technological progress and clinical uses of hydrogels in IOL manufacturing. With ongoing technological advancements, the promise of hydrogels is poised to evolve from concept to clinical reality, marking a significant leap forward in ophthalmology characterized by improved patient comfort, enhanced functionality, and reliable safety.

Details

Title
Eye of the future: Unlocking the potential utilization of hydrogels in intraocular lenses
Author
Wu, Hao 1   VIAFID ORCID Logo  ; Wang, Jiale 1 ; Fan, Wenhui 1 ; Zhong, Qi 1 ; Xue, Rongyue 1 ; Li, Siyu 1 ; Song, Zongming 2 ; Tao, Ye 1 

 Henan Eye Institute, Henan Eye Hospital, People's Hospital of Zhengzhou University, Zhengzhou, China, Zhengzhou University School of Medicine, Zhengzhou, China 
 Henan Eye Institute, Henan Eye Hospital, People's Hospital of Zhengzhou University, Zhengzhou, China 
Section
REVIEW ARTICLE
Publication year
2024
Publication date
Sep 1, 2024
Publisher
John Wiley & Sons, Inc.
e-ISSN
23806761
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3128148735
Copyright
© 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.