Abstract

This comprehensive review explores the multifaceted landscape of skin bioprinting, revolutionizing dermatological research. The applications of skin bioprinting utilizing techniques like extrusion-, droplet-, laser- and light-based methods, with specialized bioinks for skin biofabrication have been critically reviewed along with the intricate aspects of bioprinting hair follicles, sweat glands, and achieving skin pigmentation. Challenges remain with the need for vascularization, safety concerns, and the integration of automated processes for effective clinical translation. The review further investigates the incorporation of biosensor technologies, emphasizing their role in monitoring and enhancing the wound healing process. While highlighting the remarkable progress in the field, critical limitations and concerns are critically examined to provide a balanced perspective. This synthesis aims to guide scientists, engineers, and healthcare providers, fostering a deeper understanding of the current state, challenges, and future directions in skin bioprinting for transformative applications in tissue engineering and regenerative medicine.

Details

Title
Advancements in 3D skin bioprinting: processes, bioinks, applications and sensor integration
Author
Derman, I Deniz 1   VIAFID ORCID Logo  ; Rivera, Taino 2   VIAFID ORCID Logo  ; Laura Garriga Cerda 3   VIAFID ORCID Logo  ; Singh, Yogendra Pratap 1   VIAFID ORCID Logo  ; Saini, Shweta 4 ; Hasan Erbil Abaci 5   VIAFID ORCID Logo  ; Ozbolat, Ibrahim T 6   VIAFID ORCID Logo 

 Engineering Science and Mechanics Department, Penn State University , University Park, PA, United States of America; The Huck Institutes of the Life Sciences, Penn State University , University Park, PA, United States of America 
 Biomedical Engineering Department, Penn State University , University Park, PA, United States of America 
 Department of Dermatology, Columbia University Irving Medical Center , New York, NY, United States of America 
 The Huck Institutes of the Life Sciences, Penn State University , University Park, PA, United States of America 
 Department of Dermatology, Columbia University Irving Medical Center , New York, NY, United States of America; Department of Biomedical Engineering, Columbia University , New York, NY, United States of America 
 Engineering Science and Mechanics Department, Penn State University , University Park, PA, United States of America; The Huck Institutes of the Life Sciences, Penn State University , University Park, PA, United States of America; Biomedical Engineering Department, Penn State University , University Park, PA, United States of America; Materials Research Institute, Penn State University , University Park, PA, United States of America; Cancer Institute, Penn State University , University Park, PA, United States of America; Neurosurgery Department, Penn State University , University Park, PA, United States of America; Department of Medical Oncology, Cukurova University , Adana, Turkey 
First page
012009
Publication year
2025
Publication date
Feb 2025
Publisher
IOP Publishing
e-ISSN
26317990
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3130799273
Copyright
© 2024 The Author(s). Published by IOP Publishing Ltd on behalf of the IMMT. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.