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© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

This study evaluated the effects of cold-pressed maqui (Aristotelia chilensis (Mol.) Stuntz) seed oil (MO) on liver metabolism and biochemical markers in a high-fat diet (HFD) murine model. In it, the fatty acid profile, tocopherol and tocotrienol contents, and antioxidant capacity of MO were analyzed. Male C57BL/6 mice were divided into four groups (i.e., a, b, c, and d groups) and supplemented for 12 weeks according to the following distribution: (a) control diet (CD)-sunflower oil (SO), (b) CD+MO, (c) HFD+SO, and (d) HFD+MO. Total body and organ weights, serum markers, and liver fat infiltration were assessed. MO contained 32.31% oleic acid, 46.41% linoleic acid, and 10.83% α-linolenic acid; additionally, α- and γ-tocopherol levels were 339.09 ± 5.15 and 135.52 ± 38.03 mg/kg, respectively, while β-, δ-tocopherol, and α-tocotrienol were present in trace amounts and the antioxidant capacity measured was 6.66 ± 0.19 μmol Trolox equivalent/g. MO supplementation significantly reduced the visceral fat (0.76 ± 0.06 g vs. 1.32 ± 0.04 g) and GPT (glutamate pyruvate transaminase) levels (71.8 ± 5.0 vs. 35.2 ± 2.6 U/L), and the liver fat infiltration score (6 vs. 3) in the HFD+MO group compared to HFD+SO. It is suggested that MO may effectively prevent fatty liver disease, warranting further research on its potential benefits for human health.

Details

Title
Cold-Pressed Aristotelia chilensis (Mol.) Stuntz Seed Oil Prevents Metabolic-Dysfunction-Associated Steatotic Liver Disease (MASLD) in a High-Fat-Diet-Induced Obesity Murine Model
Author
Claria, Benjamín 1 ; Espinosa, Alejandra 2 ; Rodríguez, Alicia 3   VIAFID ORCID Logo  ; Dovale-Rosabal, Gretel 3   VIAFID ORCID Logo  ; Bucarey, José Luis 4   VIAFID ORCID Logo  ; Pando, María Elsa 5 ; Romero, Nalda 3   VIAFID ORCID Logo  ; Reinoso, Francisca 3 ; Sánchez, Camila 3   VIAFID ORCID Logo  ; Valenzuela, Rodrigo 5   VIAFID ORCID Logo  ; Ribeiro, Carolina H 6 ; Aubourg, Santiago P 7   VIAFID ORCID Logo 

 Department of Food Science and Chemical Technology, Faculty of Chemical and Pharmaceutical Sciences, Dr. Carlos Lorca Tobar 964, University of Chile, Santiago 8380494, Chile; [email protected] (B.C.); [email protected] (G.D.-R.); [email protected] (N.R.); [email protected] (F.R.); [email protected] (C.S.); Department of Medical Technology, Faculty of Medicine, University of Chile, Santiago 8380000, Chile; [email protected] 
 Department of Medical Technology, Faculty of Medicine, University of Chile, Santiago 8380000, Chile; [email protected]; School of Medicine, Faculty of Medicine, Universidad de Valparaíso, San Felipe 2172972, Chile; [email protected]; Center of Interdisciplinary Biomedical and Engineering Research for Health, Universidad de Valparaíso, San Felipe 2172972, Chile 
 Department of Food Science and Chemical Technology, Faculty of Chemical and Pharmaceutical Sciences, Dr. Carlos Lorca Tobar 964, University of Chile, Santiago 8380494, Chile; [email protected] (B.C.); [email protected] (G.D.-R.); [email protected] (N.R.); [email protected] (F.R.); [email protected] (C.S.) 
 School of Medicine, Faculty of Medicine, Universidad de Valparaíso, San Felipe 2172972, Chile; [email protected] 
 Department of Nutrition, Faculty of Medicine, University of Chile, Santiago 8380000, Chile; [email protected] (M.E.P.); [email protected] (R.V.) 
 Immunology Program, Biomedical Sciences Institute (ICBM), Faculty of Medicine, University of Chile, Santiago 8380000, Chile; [email protected] 
 Department of Food Technology, Marine Research Institute (CSIC), Eduardo Cabello 6, 36208 Vigo, Spain 
First page
1384
Publication year
2024
Publication date
2024
Publisher
MDPI AG
e-ISSN
20763921
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3132829572
Copyright
© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.