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© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

The main goal of this systematic review on the flavonol class secondary metabolite quercetin is to evaluate and summarize the existing research on quercetin’s potential health benefits, therapeutic properties, and effectiveness in disease prevention and treatment. In addition to evaluating quercetin’s potential for drug development with fewer side effects and lower toxicity, this type of review attempts to collect scientific evidence addressing quercetin’s roles as an antioxidant, anti-inflammatory, antibacterial, and anticancer agent. In the first part, we analyze various flavonoid compounds, focusing on their chemical structure, classification, and natural sources. We highlight their most recent biological activities as reported in the literature. Among these compounds, we pay special attention to quercetin, detailing its chemical structure, physicochemical properties, and process of biosynthesis in plants. We also present natural sources of quercetin and emphasize its health benefits, such as its antioxidant and anti-inflammatory effects. Additionally, we discuss methods to enhance its bioavailability, analyzing the latest and most effective delivery systems based on quercetin.

Details

Title
A Systematic Review: Quercetin—Secondary Metabolite of the Flavonol Class, with Multiple Health Benefits and Low Bioavailability
Author
Olimpia-Daniela Frenț 1   VIAFID ORCID Logo  ; Stefan, Liana 2 ; Claudia Mona Morgovan 3 ; Duteanu, Narcis 4   VIAFID ORCID Logo  ; Dejeu, Ioana Lavinia 1   VIAFID ORCID Logo  ; Marian, Eleonora 1   VIAFID ORCID Logo  ; Vicaș, Laura 1   VIAFID ORCID Logo  ; Manole, Felicia 2 

 Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, No. 29 Nicolae Jiga Street, 410028 Oradea, Romania; [email protected] (O.-D.F.); [email protected] (E.M.); [email protected] (L.V.) 
 Department of Surgical Discipline, Faculty of Medicine and Pharmacy, University of Oradea, 410087 Oradea, Romania 
 Department of Chemistry, Faculty of Informatics and Sciences, University of Oradea, No 1 University Street, 410087 Oradea, Romania 
 Faculty of Chemical Engineering, Biotechnologies, and Environmental Protection, Politehnica University of Timisoara, No. 2 Victoriei Square, 300006 Timişoara, Romania; National Institute of Research and Development for Electrochemistry and Condensed Matter, 144 Dr. A. P. Podeanu, 300569 Timisoara, Romania 
First page
12091
Publication year
2024
Publication date
2024
Publisher
MDPI AG
ISSN
16616596
e-ISSN
14220067
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3133094462
Copyright
© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.