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© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

With increasing evidence showing the connections between the microbiome, neurophysiology, and behavior, our research endeavors to investigate whether the consumption of a combination of two postbiotics with antioxidant effects can affect behavior regulation in model species. Here, we worked with a combination (1:1 ratio) of heat-treated Bifidobacterium longum subsp. longum ES1 (CECT7347) and Lacticaseibacillus rhamnosus BPL15 (CECT8361) as a dietary supplement. To examine the potential benefit of using this formulation to alleviate anxiety-like behavior, we employed two model species, Caenorhabditis elegans and adult Danio rerio. In C. elegans, the postbiotic supplementation reduced the anxiety-related behavior analyzed by means of the octanol avoidance test. In zebrafish, the novel tank test indicated a different swimming pattern 2 and 4 months after the animals were fed with the postbiotic combination. While fish did not exhibit any variance in their locomotion parameters such as pace and speed, they showed a statistically significant preference to spend more time in the upper zone of the water tank, a behavior that is correlated with a lower anxiety-like behavior in these species. Our aim with this study is to present evidence that can be used to develop whole-cell postbiotic-based novel and innovative dietary supplements for anxiety-related conditions.

Details

Title
The Effect of the Combination of Two Postbiotics on Anxiety-like Behavior in Animal Models
Author
Robles, Vanesa 1   VIAFID ORCID Logo  ; Balaguer, Ferran 2 ; Maicas, Miren 2 ; Martínez-Vázquez, Juan Manuel 3 ; Martorell, Patricia 2   VIAFID ORCID Logo  ; Tortajada, Marta 2 ; Daniel, Ramón 4 ; Valcarce, David G 5 

 Cell Biology Area, Molecular Biology Department, Campus de Vegazana s/n, Universidad de León, 24071 León, Spain; [email protected] 
 Archer Daniels Midland, Nutrition, Health & Wellness, Biopolis S.L. Parc Científic Universitat de València, C/Catedrático Agustín Escardino Benlloch, 9, 46980 Paterna, Spain; [email protected] (F.B.); [email protected] (M.M.); [email protected] (M.T.); [email protected] (D.R.) 
 Instituto Español de Oceanografía, Centro Oceanográfico de Santander (COST-IEO), CSIC, Calle Severiano Ballesteros 16, 39004 Santander, Spain; [email protected] 
 Archer Daniels Midland, Nutrition, Health & Wellness, Biopolis S.L. Parc Científic Universitat de València, C/Catedrático Agustín Escardino Benlloch, 9, 46980 Paterna, Spain; [email protected] (F.B.); [email protected] (M.M.); [email protected] (M.T.); [email protected] (D.R.); Animal Health and Production, Veterinary Public Health and Food Science and Technology Department Faculty of Veterinary Medicine, University Cardenal Herrera CEU, C/Tirant lo Blanc 7, 46115 Alfara del Patriarca, Spain 
 Cell Biology Area, Molecular Biology Department, Campus de Vegazana s/n, Universidad de León, 24071 León, Spain; [email protected]; Instituto Español de Oceanografía, Centro Oceanográfico de Santander (COST-IEO), CSIC, Calle Severiano Ballesteros 16, 39004 Santander, Spain; [email protected] 
First page
2006
Publication year
2024
Publication date
2024
Publisher
MDPI AG
e-ISSN
20734409
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3143984848
Copyright
© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.