Abstract

Myeloid ecotropic virus insertion site 1 (MEIS1) is a HOX co-factor necessary for organ development and normal hematopoiesis. Recently, MEIS1 has been linked to the development and progression of various cancers. However, its role in gliomagenesis particularly on glioma stem cells (GSCs) remains unclear. Here, we demonstrate that MEIS1 is highly upregulated in GSCs compared to normal, and glioma cells and to its differentiated counterparts. Inhibition of MEIS1 expression by shRNA significantly reduced GSC growth in both in vitro and in vivo experiments. On the other hand, integrated transcriptomics analyses of glioma datasets revealed that MEIS1 expression is correlated to cell cycle-related genes. Clinical data analysis revealed that MEIS1 expression is elevated in high-grade gliomas, and patients with high MEIS1 levels have poorer overall survival outcomes. The findings suggest that MEIS1 is a prognostic biomarker for glioma patients and a possible target for developing novel therapeutic strategies against GBM.

Details

Title
The impact of MEIS1 TALE homeodomain transcription factor knockdown on glioma stem cell growth
Author
Hyun-Jin, Kim 1 ; Batara, Don Carlo 1   VIAFID ORCID Logo  ; Young-Jun, Jeon 2 ; Lee, Seongsoo 3 ; Beck, Samuel 4 ; Sung-Hak, Kim 1 

1  Animal Molecular Biochemistry Laboratory, Department of Animal Science, College of Agriculture and Life Sciences, Chonnam National University, Gwangju, Republic of Korea 
2  Department of Integrative Biotechnology, Sungkyunkwan University, Suwon-si, Gyeonggi-do, Republic of Korea 
3  Gwangju Center, Korea Basic Science Institute (KBSI), Gwangju, Republic of Korea; Department of Systems Biotechnology, Chung-Ang University, Anseong-si, Gyeonggi-do, Republic of Korea 
4  Department of Dermatology, Center for Aging Research, Chobanian & Avedisian School of Medicine, Boston University, Boston, USA 
Pages
93-109
Publication year
2024
Publication date
Feb 2024
Publisher
Taylor & Francis Ltd.
ISSN
19768354
e-ISSN
21512485
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1080/19768354.2024.2327340
ProQuest document ID
3145359766
Copyright
© 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This work is licensed under the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.