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© 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Background

Increased oxidative stress (OS), resulting from the delicate balance between reactive oxygen species (ROS) production and antioxidant defense, is closely linked to sperm abnormalities and male subfertility. Elevated ROS levels particularly affect sperm quality. The vulnerability of spermatozoa to ROS is due to the absence of DNA repair mechanisms and the high presence of polyunsaturated fatty acids in their membranes.

Methods

This article updates and advances our understanding of the molecular damage caused by OS in spermatozoa, including lipid peroxidation, DNA damage, motility, and functionality. Additionally, the review discusses the challenges in diagnosing OS in semen and recommends accurate and sensitive testing methods. Case studies are utilized to demonstrate the effective management of male infertility caused by OS.

Main findings

Highlighting the need to bridge the gap between research and clinical practice, this review suggests strategies for clinicians, such as lifestyle and dietary changes and antioxidant therapies. The review emphasizes lifestyle modifications and personalized care as effective strategies in managing male infertility caused by OS.

Conclusion

This review calls for early detection and intervention and interdisciplinary collaboration to improve patient care in male infertility cases related to increased OS.

Details

Title
Oxidative stress affects sperm health and fertility—Time to apply facts learned at the bench to help the patient: Lessons for busy clinicians
Author
Sengupta, Pallav 1   VIAFID ORCID Logo  ; Pinggera, Germar‐M. 2   VIAFID ORCID Logo  ; Calogero, Aldo E. 3   VIAFID ORCID Logo  ; Agarwal, Ashok 4   VIAFID ORCID Logo 

 Global Andrology Forum, Moreland Hills, Ohio, USA, Department of Biomedical Sciences, College of Medicine, Gulf Medical University, Ajman, UAE 
 Global Andrology Forum, Moreland Hills, Ohio, USA, Department of Urology, Medical University Innsbruck, Innsbruck, Austria 
 Global Andrology Forum, Moreland Hills, Ohio, USA, Division of Endocrinology, Metabolic Diseases and Nutrition, University of Catania, Catania, Italy 
 Global Andrology Forum, Moreland Hills, Ohio, USA, Cleveland Clinic, Cleveland, Ohio, USA 
Section
MINI REVIEW
Publication year
2024
Publication date
Jan/Dec 2024
Publisher
John Wiley & Sons, Inc.
ISSN
14455781
e-ISSN
14470578
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3147268100
Copyright
© 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.