Abstract

Dear Editor, in this study, we propose a novel linkage disequilibrium information‐based noninvasive zygosity (LDNZ) assessment method in twin pregnancies. It combines fetus‐specific allele frequency analysis with LD block to reduce the number of required single nucleotide polymorphism markers and experiment costs. LDNZ method offers a noninvasive, accurate, and cost‐effective solution for zygosity assessment, addressing the need for precise obstetric care in twin pregnancies.

Details

Title
Noninvasive detection of twin zygosity using genome‐wide linkage disequilibrium information
Author
Kong, Lingrong 1   VIAFID ORCID Logo  ; Yang, Yingjun 1 ; Yuan, Chao 2 ; Wei, Xing 1 ; Zhou, Xinyao 1 ; Zhou, Jia 1 ; Xing, Ya 1 ; Zou, Gang 1 ; Sun, Qianqian 1 ; Cai, Luyao 1 ; Liang, Qiufeng 1 ; Zhang, Yao 1 ; Wang, Hongkun 1 ; Liu, Zesi 1 ; Wu, Di 2 ; Sun, Luming 3   VIAFID ORCID Logo 

 Department of Fetal Medicine & Prenatal Diagnosis Center, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China 
 Research and Development Department, Celula (China) Medical Technology Co., Ltd., Chengdu, China 
 Department of Fetal Medicine & Prenatal Diagnosis Center, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China, Department of Obstetrics, Center of Fetal Medicine & intrauterine pediatrics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China 
Section
LETTER TO THE JOURNAL
Publication year
2024
Publication date
Dec 1, 2024
Publisher
John Wiley & Sons, Inc.
e-ISSN
20011326
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3149294787
Copyright
© 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.