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© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Simple Summary

In this study, we sought to understand the role of NF2 gene mutation in the carcinogenesis of sporadic cancers. NF2 gene mutations are noted in several central nervous system tumors, solid-organ tumors, and skin cancers. We conducted a literature review on eleven different cancers with NF2 gene mutation involvement, summarizing the extent of association and specific biological pathways thought to be affected by NF2 mutations. We synthesized studies across several oncologic fields to consolidate what we know about NF2 gene mutations in cancer development. The Hippo signaling pathway is a biological pathway that is involved in eight of the eleven NF2-mutated cancers studied in this review. Although NF2 mutation has a known interaction with the Hippo signaling pathway, the specific details of this interface remain a topic for further studies.

Details

Title
Role of NF2 Mutation in the Development of Eleven Different Cancers
Author
Shervin Hosseingholi Nouri 1   VIAFID ORCID Logo  ; Nitturi, Vijay 1 ; Ledbetter, Elizabeth 1 ; English, Collin W 1 ; Lau, Sean 1 ; Klisch, Tiemo J 2 ; Patel, Akash J 3   VIAFID ORCID Logo 

 Department of Neurosurgery, Baylor College of Medicine, Houston, TX 77030, USA; [email protected] (S.H.N.); [email protected] (V.N.); [email protected] (E.L.); [email protected] (C.W.E.); [email protected] (S.L.); [email protected] (T.J.K.) 
 Department of Neurosurgery, Baylor College of Medicine, Houston, TX 77030, USA; [email protected] (S.H.N.); [email protected] (V.N.); [email protected] (E.L.); [email protected] (C.W.E.); [email protected] (S.L.); [email protected] (T.J.K.); Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, Houston, TX 77030, USA 
 Department of Neurosurgery, Baylor College of Medicine, Houston, TX 77030, USA; [email protected] (S.H.N.); [email protected] (V.N.); [email protected] (E.L.); [email protected] (C.W.E.); [email protected] (S.L.); [email protected] (T.J.K.); Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, Houston, TX 77030, USA; Department of Otolaryngology–Head & Neck Surgery, Baylor College of Medicine, Houston, TX 77030, USA 
First page
64
Publication year
2025
Publication date
2025
Publisher
MDPI AG
e-ISSN
20726694
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3153541768
Copyright
© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.