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© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Simple Summary

The extension of the radiotherapy field from only the pelvic region to a pelvic and para-aortic (PAO) region in advanced cervical cancer depends on the presence of common iliac and/or PAO lymph nodes suspicious for metastases on a CT scan or PET CT scan. However, in the presence of multiple tumor-positive pelvic lymph nodes (≥3), this extension of the radiotherapy field is also recommended because of the substantial risk of PAO metastases. If this risk of PAO metastases is also substantial in clinically early cervix cancer with multiple positive pelvic lymph nodes, it is controversial. We found a risk of 2.4% for isolated PAO recurrence after a radical hysterectomy and pelvic lymphadenectomy followed by adjuvant pelvic radiotherapy of early cervix cancer, where ≥3 positive pelvic lymph nodes were found. This frequency did not differ from patients with <3 positive pelvic nodes. The fact that the frequency of PAO recurrences is relatively low makes it very unlikely that the extension of the radiotherapy field to the PAO region will result in better survival for these patients with clinical early cervix cancer.

Details

Title
Impact of the Number of Positive Pelvic Lymph Nodes on Risk of Para-Aortic Recurrence in Patients with Clinically Early Cervical Cancer Treated by a Radical Hysterectomy and Pelvic Lymphadenectomy
Author
Schoonhoven, Felix J M 1   VIAFID ORCID Logo  ; Aarts, Johanna W M 1   VIAFID ORCID Logo  ; Fons, Guus 1 ; Stalpers, Lukas J A 2 ; Luc R C W van Lonkhuijzen 1   VIAFID ORCID Logo  ; Jacobus van der Velden 1   VIAFID ORCID Logo  ; Mom, Constantijne H 1   VIAFID ORCID Logo 

 Department of Gynecological Oncology, Centre for Gynecologic Oncology Amsterdam (C.G.O.A.), Amsterdam University Medical Center, 1081 HV Amsterdam, The Netherlands; [email protected] (F.J.M.S.); [email protected] (J.W.M.A.); [email protected] (G.F.); [email protected] (L.R.C.W.v.L.); [email protected] (C.H.M.) 
 Department of Radiation Oncology, Amsterdam University Medical Center, 1055 AZ Amsterdam, The Netherlands; [email protected] 
First page
23
Publication year
2025
Publication date
2025
Publisher
MDPI AG
e-ISSN
20726694
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3153541785
Copyright
© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.