Full text

Turn on search term navigation

© 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Determining the values of various properties for new bio-inks for 3D printing is a very important task in the design of new materials. For this purpose, a large number of experimental works have been consulted, and a database with more than 1200 bioprinting tests has been created. These tests cover different combinations of conditions in terms of print pressure, temperature, and needle values, for example. These data are difficult to deal with in terms of determining combinations of conditions to optimize the tests and analyze new options. The best model demonstrated a specificity (Sp) of 88.4% and a sensitivity (Sn) of 86.2% in the training series while achieving an Sp of 85.9% and an Sn of 80.3% in the external validation series. This model utilizes operators based on perturbation theory to analyze the complexity of the data. For comparative purposes, neural networks have been used, and very similar results have been obtained. The developed tool could easily be applied to predict the properties of bioprinting assays in silico. These findings could significantly improve the efficiency and accuracy of predictive models in bioprinting without resorting to trial-and-error tests, thereby saving time and funds. Ultimately, this tool may help pave the way for advances in personalized medicine and tissue engineering.

Details

Title
Artificial Intelligence-Driven Modeling for Hydrogel Three-Dimensional Printing: Computational and Experimental Cases of Study
Author
Bediaga-Bañeres, Harbil 1   VIAFID ORCID Logo  ; Moreno-Benítez, Isabel 2   VIAFID ORCID Logo  ; Arrasate, Sonia 2 ; Pérez-Álvarez, Leyre 3   VIAFID ORCID Logo  ; Halder, Amit K 4   VIAFID ORCID Logo  ; M Natalia D S Cordeiro 5   VIAFID ORCID Logo  ; González-Díaz, Humberto 6   VIAFID ORCID Logo  ; Vilas-Vilela, José Luis 3   VIAFID ORCID Logo 

 Department of Physical Chemistry, University of Basque Country UPV/EHU, 48940 Leioa, Spain; [email protected] (H.B.-B.); [email protected] (L.P.-Á.) 
 Department of Organic and Inorganic Chemistry, University of Basque Country UPV/EHU, 48940 Leioa, Spain; [email protected] (S.A.); [email protected] (H.G.-D.) 
 Department of Physical Chemistry, University of Basque Country UPV/EHU, 48940 Leioa, Spain; [email protected] (H.B.-B.); [email protected] (L.P.-Á.); BCMaterials, Basque Center for Materials, Applications and Nanostructures, UPV/EHU Science Park, 48940 Leioa, Spain 
 LAQV-REQUIMTE, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal; [email protected] (A.K.H.); [email protected] (M.N.D.S.C.); Dr. B. C. Roy College of Pharmacy and Allied Health Sciences, Durgapur 713206, India 
 LAQV-REQUIMTE, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal; [email protected] (A.K.H.); [email protected] (M.N.D.S.C.) 
 Department of Organic and Inorganic Chemistry, University of Basque Country UPV/EHU, 48940 Leioa, Spain; [email protected] (S.A.); [email protected] (H.G.-D.); Basque Center for Biophysics, CSIC-UPV/EHU, 48940 Leioa, Spain; IKERBASQUE, Basque Foundation for Science, 48011 Bilbao, Spain 
First page
121
Publication year
2025
Publication date
2025
Publisher
MDPI AG
e-ISSN
20734360
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3153584910
Copyright
© 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.