Abstract

The modulation of the host innate immune system is a well-established carcinogenesis feature of several tumors, including human Epstein-Barr (EBV) and Papillomavirus-(HPV) related cancers. These viruses are able to interrupt the initial events of the immune response, including the expression of Toll-like receptors (TLRs), cytokines, and inflammation. The aim of the study is to review current data and summarize knowledge on the TLRs and their role in the development of cancer, especially viral-related cancers (EBV and HPV). Research work shows a correlation between the TLRs polymorphism and the development of oropharyngeal and gastric cancer (GC), especially related to viral infections. Many studies suggest the important role for TLRs in inflammatory, autoimmune disease and human cancers. However, further efforts are necessary to draw a precise conclusion.

Details

Title
The role of Toll-like receptors (TLRs) in virus-related cancers: a mini review
Author
Dworzanska, Anna 1   VIAFID ORCID Logo  ; Polz-Dacewicz, Małgorzata 2   VIAFID ORCID Logo 

1  Masovian Specialist Hospital, 26-617 Radom, Poland 
2  Department of Virology, Medical University of Lublin, 20-059 Lublin, Poland 
Pages
225-227
Publication year
2020
Publication date
2020
Publisher
De Gruyter Poland
ISSN
2084980X
e-ISSN
23006676
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.2478/cipms-2020-0038
ProQuest document ID
3156089751
Copyright
© 2020. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0 (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.