Contemporary situation of community-acquired pneumonia in China: A systematic review

Abstract

The prevalence and microbial pattern reported for Community-acquired pneumonia (CAP) differ considerably and contemporary situation remains changing over time. We therefore searched both international and domestic databases for relevant references and pooled incidence of CAP and etiological distribution were estimated separately between children and adults groups. The results showed that CAP remained a major public health issue in China, with a relatively higher incidence than that reported in Western countries. Although pathogens were not detected in nearly half of patients, Mycoplasma pneumoniae remained to be the most frequently detected agent across age groups, the detection yield of which was lower than that reported from other countries. Notably, the incidence of influenza virus A in adults was almost four times higher than that in children while the prevalence of respiratory syncytial virus was much less common in adults than that in children. Despite some limitations, the value of this review, approaching to systematically review grey published data, is to sketch out the contemporary epidemiological and etiological situation of CAP in our country, which could be useful to help policymakers and clinicians make informed choices and to inspire future studies and surveillance.

Introduction

Although community-acquired pneumonia (CAP) remains a common disease with high mortality and economic cost, the prevalence and microbial pattern reported for CAP differ considerably worldwide, depending on epidemiologic area, patient populations, and the extent and nature of the microbiologic techniques used.[1,2] Knowledge of predominant microbial patterns in CAP, as a consensus, constitutes the basis for guiding the empirical antimicrobial treatment.[3,4] Contemporary estimates of the nationwide incidence and microbiologic causes for CAP would be of great value. However, the last multi-center publicationof etiology of CAP in Chinese urban population was almost a decade ago and situation remained changing over time.[5] We, therefore, performed a systematic literature review from both international and domestic databases to summarize some of the most concerning questions in CAP such as incidence, etiological distribution and resistance to antibiotics in China.

Methods

We searched PubMed, EMBASE and Web of Science as well as nationwide recognized databases such as WanFang (wanfangdata.com.cn), National Knowledge Infrastructure (cnki.net) and CQVIP (cqvip. com) for relevant studies published up toJan 2017. Given the aim of our review, we mainly focused on prevalence, pathogen detection rate, etiological distribution and antibiotic resistance. Pooled incidence of CAP and etiological distribution were estimated separately between children and adults groups.

Results

Incidence

Two hundred andsixty-nine publications were finally included with 154 publications for adults and 115 for children. The incidence of CAP ranged from 29.8 to 221.0 per 10,000 admissions. The proportion of elderly cases (65 years of age or older) among all CAP patients was 37.2% ± 7.9%. The trial with largest scale population (Guangdong, 2009) suggested that the incidence of CAPincreasedfrom 0.22% (8,677/3,893,800) in 2009 to 0.41%(19,947/4,839,766) in 2012 and mortality rate was highest among elderly patients (65 years of ageor older) (4.70%, 224/4,763). The incidence was similar across genders and different seasons.

Detection of Pathogens

Overall, the pathogens detected yield among adults was 51.0% ± 17.9% and that among children was 52.0% ± 18.1% (Figure 1). No significant differences of rate between adults and children were observed among different regions throughout the country (Northern, 49.8% vs. 55.0%; Eastern, 47.7% vs. 51.4%; Central & Southern, 54.0% vs. 53.7%; Western, 56.3% vs. 47.4%).

Figure 1 Overall pathogens detected yield among adults and children depending on regions. (A) Overall pathogens detected yield among adults and children; (B) Pathogens detected yield depending on designed regions; (C) Colors labeled on the map of China showed the designed areas in Panel C. Yellow (Northern area): provinces of Beijing, Tianjin, Heilongjiang, Jilin, Liaoning, Hebei, Henan, Shan(1)xi and Inner Mongolia. Red (Eastern area): provinces of Shanghai, Jiangsu, Zhejiang, Shandong, Anhui and Fujian. Green (Central & Southernarea): provinces of Hubei, Hunan, Jiangxi, Guangdong, Guangxi and Hainan. Blue (Western area): provinces of Shan(3)xi, Sichuan, Chongqing, Guizhou, Yunnan, Ningxia, Gansu, Qinghai, Xinjiang and Tibet.

The distribution of overall etiology was shown in Figure 2. Mycoplasmapneumoniae was the most common agent among adults, identified in 15.01% of patients, followed by Streptococcuspneumoniae in 11.68%, Influenza virus A in 12.28% and fungi in 8.28%. On the other hand, Mycoplasmapneumoniae was also the most common agent among children, identified in 19.16% of patients, followed by Respiratorysyncytial virus in 16.01%, Streptococcuspneumoniae in 9.44% and Klebsiellapneumoniae in 7.77%. Specifically, significant differences on the detected rate of Escherichiacoli and Pseudomonas aeruginosa were found between adults and children (3.88% vs. 6.95%, P <0.05 and 4.37% vs. 1.22%, P <0.05, respectively).

Figure 2 The overall estimated distribution of CAP etiology. N = 154 in adult publications, N = 115 in kid publications.

The fungi were detected more commonly in adults than in children (8.28% vs. 1.76%, P <0.01). The frequency of Influenza virus A in adults was significantly higher than that in children (12.28% vs. 3.73%, P <0.01) while the frequency of Respiratory syncytial virus (RSV) in children was significantly higher than that in adults (16.01% vs. 1.24%, P <0.001).

Antimicrobial susceptibility

A total of 93 publications (50 in adults and 43 in children) submitted Streptococcuspneumoniaefor antimicrobial susceptibility testing. The proportions of intermediately/fully resistant isolates to penicillin from adult and child patients were 43.33% and 55.68%, respectively. However, no statistical difference was found between two groups.

Discussion

Although several multi-center studies regarding nation-wide epidemiology and etiology of CAP have been published recently,[5,7,8] the contemporary situation in reality remains attractive. The main reason results fromhuge publication biasbecause most Chinese clinical researchers have limited English writing skills, which means we probably failed to notice valuable data sealed within Chinese databases. The present review, therefore, is the first to systematically analyze several concerning questions on CAP from both international and domestic resources. The results, combined from all ages, revealed a relatively higher incidence (29.8 to 221.0 cases per 10,000 persons) of CAP than that reported among adults (24.8 to 26.7 cases per 10,000 adults)[1] or children(15.7 to 22.5 cases per 10,000 children younger than 18 years old)[2] in USA. Despite of large scale of admission population, existing data mainly originated from developed urban areas with a more sophisticated hygienic system compared to rural areas, which means that hospitals, in those cities, were more accessible to the public. The other possibility wasthat theinfluence of immigrants from nearby counties seeking for better medical resourceswould contribute to this increasing morbidity in urban areas. However, those limited investigations were not sufficient to depict the whole figure of the country.

According to the previous studies, atypical pathogens, including M. pneumoniae, C. pneumoniae, and L. pneumophila, have been reported more frequently over time, responsible for 20 to 40% of cases of CAP.[5,9,10] Although our combined data in China revealed M.pneumoniaeremained the most prevalent etiologic agent across age groups, the detection yield was only 15.01% and 19.16% in adults and children respectively. The notable explanationwas that majority of reports relied exclusively on serologic testing, which has less specificity than the PCR assay.[11,12,13] Since M. pneumoniaewas frequently found in mixed infections, multiple simultaneous infections might interfere with the pulmonary cleansing function and thus help establish setting for CAP.[14,15] Atypical pathogens, probably in most cases, caused primary atypical pneumonia and secondary bacterial infections, which had the possibility of missingpreceding pathogenicinsults by clinical practitioners. More specifically in China, some patients arbitrarily received pre-preserved antibiotics such as macrolides or β-lactams instead of going to the hospital, which could attribute to the bias of low prevalence because all the populations withinthe existing publications were originated from hospital.

S. pneumoniaeremained the leading bacterial cause of both adult and children CAP in our country, followed by Klebsiellapneumoniae, surprisingly, across age groups. Since urinary antigen tests for pneumoncoccus were more sensitive than blood culture and improved the detection of nonbacteremic pneumococcal pathogens with a reported sensitivity of 70% and a specificity of 90%,[16,17,18] they were responsible for the pneumococcal detections in a growing amount of studies. Moreover, the high proportion of S. pneumoniae infection provided a sufficient reason to keep on promotingpneumococcal vaccination especially among children and persons 65 years of age or older.[19] To date, antibiotic resistance in S. pneumoniae is still considered to be a nationwide problem. The combined non-susceptibility to penicillin was as high as 55% in our review, which was higher than the yield reported by CHINET (Chinese network for surveillance of resistant pathogens), accounting for 32.9% in children and 9.2% in adults in 2013.[20] This network also reported high resistance to macrolides among S. pneumoniae in China (over 90% to erythromycin), which is another characteristic difference compared with European/American countries. Although new fluoroquinolones have good activities against S. pneumoniae, the resistance rate of new fluoroquinolones is increasing over time, accounting for up to 15% to levofloxacin among adults in 2013,[20] which is possibly a result of selective pressure due to increased quinolone use in China.

Influenza virus A was the most commonly detected virus among adults. The incidence of influenza virus A was almost four times higher than that among children (12.28% vs. 3.73%), which underscored the need for improvements in influenza-vaccine uptake and effectiveness[21].Notably, all eligible studies were not specifically conducted during the 2009 H1N1 influenza pandemic period, which might result in the burden of influenza A less than it would be during seasons with more widespread circulation.On the other hand, similar to results from US,[2] RSV was the most common pathogen detected in children, with the greatest burden observed among children younger than 2 years of age. Given the large proportion and diversity of virus co-infected with other causative agents, all the findings abovesuggested the potential underestimation of the contribution of viruses to pneumonia in our country and highlighted the usefulness of molecular methods for the detection of respiratory virus agents.[22]

Our review has certain limitations due to the patchy availability of data. First, most sources of data failed to distinguish the sub-population of adolescents, 15 to 18 years old, from adults, which could bias the epidemiological or etiological findings classified by age. Our review also analyzed few data at 1^st or 2^nd-tier hospital level, which probably represents a high caseload in China. Second, diagnostic methods varied among all the publications, which could have led to underestimation or overestimation of the pathogen-specific rates. Owing to the ethical and feasibility considerations, invasive procedures to obtain specimens directly from the lung were not usually performed, which may have reduced the microbiologic yield.[23] The causal role of sputum or blood cultured bacteria to identify CAP etiologies, however, has also been debated in some cases, particularly in the elderly with comorbidities or children younger than 5 years old since they may not discriminate between infection and colonization.[24] Third, in some cases, the clinical and radiographic features of pneumonia overlap with those of other syndromes such as chronic lung disease or congestive heart failure in the elderly and bronchiolitis or reactive airway disease in young children respectively. Even strict definitions may not accurately distinguish among these entities, resulting in potential misclassification.[25] This situation is consistent with the worldwide challenges of diagnosing pneumonia and of its subsequent management.

Conclusion

CAP remained a major public health issue in China, with a relatively higher incidence than that reported in Western countries.Although pathogens were not detected in nearly half of patients, Mycoplasmapneumoniae remained to be the most frequently detected agent across age groups, the detection yield of which was lower than that reported from other countries. Notably, the incidence of influenza virus A in adults was almost four times higher than that inchildrenwhile the prevalence of respiratorysyncytial virus was much less common in adults than that in children.Several concerns should be realized including 1) the influence of immigrants from rural counties seeking for better medical resourcesin relatively developed urban areas with a more sophisticated hygienic system, 2) the arbitrary administration of pre-preserved antibiotics such as macrolides or β-lactams without any recommendation from doctors, 3) the potential underestimation of the proportion of viral pneumonia as well as the usefulness of molecular methods for the detection of respiratory virus agents and 4) the sustainable need to promote pneumococcal vaccination especially among children and persons 65 years of age or older and improve influenza-vaccine uptake and effectiveness among adults. Despite some limitations, the value of this review, approaching to systematically review grey published data, is to sketch out the contemporary epidemiological and etiological situation of CAP in our country, which could be useful to help policymakers and clinicians make informed choices and to inspire future studies and surveillance.

Source of Foundation

This work was supported by grants from excellent youth talent project of Shanghai Municipal commission of health and family planning (No. 2017YQ081) and Shanghai key discipline for respiratory diseases (No. 2017ZZ02014).

Conflict of interest: We declare that we have no conflict of interest.

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