Abstract

Apocrine adenocarcinoma is a rare form of sweat gland malignancy mostly affecting adults without evident prevalence for sex or race. Clinically, it presents as a single or a multi-nodular mass or plaque in the axillary or anogenital region, with no additional symptoms. This neoplasm is locally invasive, grows slowly and has an ability to metastasize to visceral organs, regional lymph nodes and bones. We report a case of infiltrating apocrine adenocarcinoma on the scrotum and pubic area with extramammary pagetoid spread into the groin. The immunohistological staining patterns suggested that both extramammary Paget’s disease and apocrine adenocarcinoma derived from the apocrine gland, because the tumor cells were positive for cytokeratin (CK) 7 and gross cystic disease fluid protein-15 (GCDFP-15), but negative for CK20 and prostate-specific antigen (PSA). The results of this case study will facilitate the understanding of this malignant tumor.

Details

Title
Apocrine Adenocarcinoma with Extramammary Pagetoid Spread into the Groin: a Case Report and a Literature Review
Author
Lekić, Branislav 1 ; Gajić-Veljić, Mirjana 2 ; Škiljević, Dušan 2 ; Popadić, Svetlana 2 ; Medenica, Ljiljana 2 

 Clinic of Dermatovenereology, Clinical Center of Serbia, Belgrade, Serbia 
 Clinic of Dermatovenereology, Clinical Center of Serbia, Belgrade, Serbia Serbia; Department of Dermatovenereology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia 
Pages
201-206
Publication year
2016
Publication date
2016
Publisher
De Gruyter Poland
ISSN
18210902
e-ISSN
24060631
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3158420984
Copyright
© 2016. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0 (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.