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© 2025. This work is published under http://creativecommons.org/licenses/by-nc/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Cancer stem cells aggregate to form clusters, which have enhanced stem‐like properties and metastasis potential. However, the molecular mechanisms underlying the formation of cancer stem cell cluster‐like structures with acquisition of stronger invasion and metastasis abilities remain unclear. Micropapillary carcinoma (MPC) is a subpopulation of small, merulioid, inverted, nonfibrous vascular clusters floating in the stroma present in a range of solid malignant tumors and characterized by frequent vascular/lymphatic vessel invasion and lymph node metastasis. Our results showed that these cell clusters exhibit a stem cell phenotype, supporting the premise that MPC may serve as a promising solid tumor model for studying invasion and metastasis of cancer stem cell clusters. In this review, we discuss the latest advances in MPC research and targeted therapy, focusing on analysis of their stem‐like characteristics, mapping their multiomics characteristics, and elucidating the vascular and immune microenvironment of MPC. The existing MPC organoid model was employed to explore potential breakthroughs in targeted therapy and immunotherapy for cancer stem cell clusters.

Details

Title
Micropapillary structure: A natural tumor collective invasion model with enhanced stem‐like properties
Author
Li, Sisi 1   VIAFID ORCID Logo  ; Gao, Shuangshu 2 ; Qin, Ling 1 ; Ding, Caixia 1 ; Qu, Jinghui 1 ; Cui, Yifei 1 ; Qiang, Lixia 3 ; Yin, Shengjie 4 ; Zheng, Xiaoyu 5 ; Meng, Hongxue 1 

 Department of Pathology, Harbin Medical University Cancer Hospital, Harbin, China 
 Department of Pathology, Harbin Medical University, Harbin, China 
 Department of Respiratory Medicine, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China 
 Department of Medical Oncology, Municipal Hospital of Chifeng, Chifeng, China 
 Department of Anesthesiology, Harbin Medical University Cancer Hospital, Harbin, China 
Pages
308-321
Section
REVIEW ARTICLE
Publication year
2025
Publication date
Feb 1, 2025
Publisher
John Wiley & Sons, Inc.
ISSN
13479032
e-ISSN
13497006
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3162123056
Copyright
© 2025. This work is published under http://creativecommons.org/licenses/by-nc/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.