Abstract

Purpose

An earlier multicenter phase III study demonstrated the safety and efficacy of mitoxantrone hydrochloride injection for tracing (MHI) for detecting sentinel lymph nodes (SLNs) in breast cancer patients. This ancillary study was conducted to further analyze and discover differences between the two tracers that had not been reported previously.

Methods

This analysis used single-center data from a phase III trial. Patients with breast cancer were injected with both MHI and 99mTc as SLN tracers before surgery. To account for cluster effects of multiple SLNs from the same patient and further analyze the differences between the two methods and factors that could impact detection, Obuchowski’s modified McNemar test, the GLIMMIX model, and univariate and multivariate analyses were used as appropriate.

Results

In total, 463 SLNs from 109 patients were resected, 47 of which were pathologically positive. The SLN detection rate did not significantly differ between MHI and 99mTc. MHI blue staining was an independent predictor of pathological positivity (OR 3.58, 95% CI: 1.21–10.60, p = 0.02), while the 99mTc signal was not significant in the same model (p = 0.39).

Conclusion

MHI was comparable to 99mTc in safety and SLN detection rates but differed in sensitivity on positive SLNs.

Details

Title
A comparative study of mitoxantrone hydrochloride injection and technetium-99 m for tracing axillary sentinel nodes in patients with breast cancer
Author
Jiao, Dechuang; Chen, Xiuchun; Sun, Xianfu; Lu, Zhenduo; Dai, Hao; Wang, Chengzheng; Zhang, Chongjian; Li, Lianfang; Qiao, Jianghua; Liu, Zhenzhen
Pages
1-7
Section
Research
Publication year
2025
Publication date
2025
Publisher
BioMed Central
e-ISSN
14712407
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3165516438
Copyright
© 2025. This work is licensed under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.