Abstract

Background

The Enterics for Global Health (EFGH) Peru site will enroll subjects in a periurban area of the low Amazon rainforest. The political department of Loreto lags behind most of Peru in access to improved sources of water and sanitation, per capita income, children born <2.5 kg, and infant and child mortality. Chronic undernutrition as manifested by linear growth shortfalls is common, but wasting and acute malnutrition are not.

Methods

The recruitment of children seeking care for acute diarrheal disease takes place at a geographic cluster of government-based primary care centers in an area where most residents are beneficiaries of free primary healthcare.

Results

Rates of diarrheal disease, dysentery, and Shigella are known to be high in the region, with some of the highest rates of disease documented in the literature and little evidence in improvement over the last 2 decades. This study will update estimates of shigellosis by measuring the prevalence of Shigella by polymerase chain reaction and culture in children seeking care and deriving population-based estimates by measuring healthcare seeking at the community level.

Conclusions

Immunization has been offered universally against rotavirus in the region since 2009, and in a context where adequate water and sanitation are unlikely to obtain high standards in the near future, control of principal enteropathogens through immunization may be the most feasible way to decrease the high burden of disease in the area in the near future.

Details

Title
The Enterics for Global Health (EFGH) Shigella Surveillance Study in Peru
Author
Katia Manzanares Villanueva 1 ; Tackeshy Pinedo Vasquez 1 ; Yori, Pablo Peñataro 2 ; Lucero Romaina Cacique 1 ; Garcia Bardales, Paul F 1 ; Wagner V Shapiama Lopez 1 ; Fiorella Zegarra Paredes 1 ; Perez, Karin F 1 ; Silvia Rengifo Pinedo 1 ; Hermann Silva Delgado 3 ; Flynn, Thomas 2 ; Schiaffino, Francesca 2 ; Colston, Josh M 2 ; Maribel Paredes Paredes Olortegui 1 ; Kosek, Margaret N 2 

 Asociación Benéfica Prisma , Unidad de Investigaciones Biomedicas, Iquitos, Loreto , Peru 
 Division of Infectious Diseases and International Health, School of Medicine, University of Virginia , Charlottesville, Virginia , USA 
 Facultad de Medicina Humana, Universidad Nacional de la Amazonia Peruana , Iquitos, Loreto , Peru 
Pages
S121-S128
Publication year
2024
Publication date
Mar 2024
Publisher
Oxford University Press
e-ISSN
23288957
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3168667641
Copyright
© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.