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Abstract
Background
Despite new therapeutics, the prognosis for pancreatic cancer remains poor. Pancreatic surgery is a therapeutic option in non-metastatic forms. The consequences for renal function are poorly described.
Methods
Patients who underwent surgery for pancreatic cancer between 1 January 2010 and 1 January 2017 and who experienced kidney biopsy in the Pitié-Salpêtrière Hospital were analysed.
Results
Two hundred and ninety-four patients had pancreatic surgery during the period of analysis and five of them had a kidney biopsy (mean ± SD 20 months ±13.6 months after surgery) during the post-operative follow-up. Among these patients, three exhibited oxalate nephropathy (ON), indicating that the prevalence of ON in patients with pancreatectomy is at least 1%. ON may be insidious, with chronic renal failure without urinary abnormalities. All patients had a high oxalate-to-creatinine ratio in urine sample. Renal function improved after specific management of ON in two patients. Pancreaticoduodenectomy may represent a higher risk of ON than left pancreatectomy.
Conclusion
Although rare and underestimated, ON appears to be a real risk after pancreatic resection. Early detection may preserve renal function.
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Details
1 Nephrology Department, Pitié-Salpêtrière University Hospital, Assistance Publique des Hôpitaux de Paris, Paris, France; Division of Nephrology, RAMSAY-Générale de Santé, Hôpital privé de l'Ouest Parisien, Trappes, France
2 Nephrology Department, Pitié-Salpêtrière University Hospital, Assistance Publique des Hôpitaux de Paris, Paris, France; Division of Oncology, RAMSAY-Générale de Santé, Hôpital Privé Les Peupliers, Paris, France
3 Pathology Department, Pitié-Salpêtrière University Hospital, Assistance Publique des Hôpitaux de Paris, Paris, France
4 Oncology Department, Pitié-Salpêtrière University Hospital, Assistance Publique des Hôpitaux de Paris, Paris, France
5 Department of Hepato Pancreato Biliary Surgery, Pitié-Salpêtrière University Hospital, Assistance Publique des Hôpitaux de Paris, Paris, France
6 Physiology Unit, Tenon University Hospital, Assistance Publique des Hôpitaux de Paris, Paris, France
7 Nephrology Department, Pitié-Salpêtrière University Hospital, Assistance Publique des Hôpitaux de Paris, Paris, France