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Abstract
ABSTRACT
Background
This observational cohort study compared the likelihood of maintained (stabilized/up-titrated) renin–angiotensin–aldosterone system inhibitor (RAASi) therapy at 6 months following hyperkalaemia in patients with chronic kidney disease (CKD) and/or heart failure (HF) from the USA, Japan and Spain who received sodium zirconium cyclosilicate (SZC) for at least 120 days, relative to those with no prescription for a potassium (K+) binder.
Methods
Using health registers and hospital medical records, patients with CKD and/or HF receiving RAASi therapy who experienced a hyperkalaemia episode were identified. Propensity score (PS) matching (1:4) was applied to balance the SZC cohort to the no K+ binder cohort on baseline characteristics. Logistic regression analysis was performed to compare the odds of maintained RAASi therapy at 6 months in the SZC versus no K+ binder cohorts.
Results
The PS-matched SZC cohort included 565 (USA), 776 (Japan) and 56 (Spain) patients; the no K+ binder cohort included 2068, 2629 and 203 patients, respectively. At 6 months, 68.9% (USA), 79.9% (Japan) and 69.6% (Spain) in the SZC cohorts versus 53.1% (USA), 56.0% (Japan) and 48.3% (Spain) in the no K+ binder cohorts had maintained RAASi therapy. Meta-analysed across countries, the odds ratio of maintained RAASi therapy in the SZC cohort versus no K+ binder cohort was 2.56 (95% confidence interval 1.92–3.41; P < .0001).
Conclusions
In routine clinical practice across three countries, patients treated with SZC were substantially more likely to maintain guideline-concordant RAASi therapy at 6 months following hyperkalaemia relative to patients with no K+ binder treatment.
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Details
1 Department of Medicine, David Geffen School of Medicine, University of California Los Angeles , Los Angeles, CA , USA
2 Department of Emergency Medicine, University of Mississippi School of Medicine , Jackson, MS , USA
3 Cardiology Department, Hospital Universitari i Politècnic La Fe , Valencia , Spain
4 BioPharmaceuticals Medical CVRM Evidence, AstraZeneca , Gothenburg , Sweden
5 Real World Science and Digital, AstraZeneca , Cambridge , UK
6 Medical & Payer Evidence Statistics, AstraZeneca , Gothenburg , Sweden
7 BioPharmaceuticals Medical CVRM, AstraZeneca , Cambridge , UK
8 Atrys Health , Madrid , Spain
9 Department of Cardiology, Nagoya University Graduate School of Medicine , Nagoya , Japan
10 Department of Medical Science, Kawasaki Medical School , Okayama , Japan