Abstract

Light and heavy chain deposition disease (LHCDD) is a rare complication of monoclonal gammopathy. In all documented cases, LHCDD is the association of deposits of a monoclonal light chain with a normal heavy chain, especially in the kidneys. We describe here a 78-year-old woman whose renal biopsy showed nodular glomerulosclerosis, initially diagnosed as diabetic nephropathy. Detailed kidney biopsy immunofluorescence study corrected the diagnosis to γ1-κ-LHCDD. Advanced immunoblot analysis showed deletion of CH1 in the both blood and kidney heavy chain. We report here, to our knowledge, the first case of γ1 LHCDD associated with a deletion of CH1.

Details

Title
Light and heavy chain deposition disease associated with CH1 deletion
Author
Cohen, Camille 1 ; El-Karoui, Khalil 1 ; Marie-Alexandra Alyanakian 2 ; Laure-Hélène Noel 3 ; Bridoux, Franck 4 ; Knebelmann, Bertrand 1 

1  Service de néphrologie, hôpital Necker, Paris, France 
2  Service d'immunologie, hôpital Necker, Paris, France 
3  Service d'anatomo-pathologie, hôpital Necker, Paris, France 
4  Service de néphrologie, CHU Poitiers, Poitiers, France 
Pages
237-239
Publication year
2015
Publication date
Apr 2015
Publisher
Oxford University Press
ISSN
20488505
e-ISSN
20488513
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1093/ckj/sfv002
ProQuest document ID
3170125102
Copyright
© The Author 2015. Published by Oxford University Press on behalf of ERA-EDTA. This work is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.